Synonym
LY 207702; LY-207702; LY207702.
IUPAC/Chemical Name
2',2'-Difluorodeoxyribofuranosyl-2,6-diaminopurine
InChi Key
UPHLSICWROERBL-CUAOIRRQSA-N
InChi Code
InChI=1S/C10H12F2N6O3/c11-10(12)4(20)2(1-19)21-5(10)8-15-3-6(13)16-9(14)18-7(3)17-8/h2,4-5,19-20H,1H2,(H5,13,14,15,16,17,18)/t2-,4-,5?/m1/s1
SMILES Code
NC1=C2NC(C3C(F)(F)[C@@H]([C@@H](CO)O3)O)=NC2=NC(N)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
302.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Patel VF, Hardin JN, Mastro JM, Law KL, Zimmermann JL, Ehlhardt WJ, Woodland JM, Starling JJ. Novel acid labile COL1 trityl-linked difluoronucleoside immunoconjugates: synthesis, characterization, and biological activity. Bioconjug Chem. 1996 Jul-Aug;7(4):497-510. PubMed PMID: 8853464.
2: Andis SL, Bewley JR, Boder GB, Burke T, Dudley DE, Eichelberger LE, Grossman CS, Grindey GB, Hertel LW, Jordan CL, et al. Medicinal chemistry of difluoropurines. Semin Oncol. 1995 Aug;22(4 Suppl 11):54-60. PubMed PMID: 7481846.
