LY 195448 | CAS#111112-18-6

MedKoo Cat#: 525507 | Name: LY 195448

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 195448 is a phenethanolamine that has shown anti-tumour activity. LY 195448 blocks cells at metaphase.

Chemical Structure

LY 195448

CAS#111112-18-6

Theoretical Analysis

MedKoo Cat#: 525507

Name: LY 195448

CAS#: 111112-18-6

Chemical Formula: C20H27ClN2O2

Exact Mass:

Molecular Weight: 362.90

Elemental Analysis: C, 66.19; H, 7.50; Cl, 9.77; N, 7.72; O, 8.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

LY 195448; LY195448; LY-195448; UNII-BR0DFE3GF6.

IUPAC/Chemical Name

(R)-4-(3-((2-Hydroxy-2-phenethyl)amino)-3-methylbutyl)benzamide monohydrochloride

InChi Key

PFTVHDSGCARRKR-FERBBOLQSA-N

InChi Code

InChI=1S/C20H26N2O2.ClH/c1-20(2,22-14-18(23)16-6-4-3-5-7-16)13-12-15-8-10-17(11-9-15)19(21)24;/h3-11,18,22-23H,12-14H2,1-2H3,(H2,21,24);1H/t18-;/m0./s1

SMILES Code

O=C(N)C1=CC=C(CCC(C)(NC[C@H](O)C2=CC=CC=C2)C)C=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 362.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barlow SB, Cabral F. Alterations in microtubule assembly caused by the microtubule-active drug LY195448. Cell Motil Cytoskeleton. 1991;19(1):9-17. PubMed PMID: 1863984. 2: Engineer MS, Newman RA. High-performance liquid chromatographic measurement of (R)-4-[3-[(2-hydroxy-2-phenethyl)amino]-3-methylbutyl]benzamide monohydrochloride (LY195448) and its p-hydroxy metabolite in human plasma and urine. J Chromatogr. 1990 May 18;527(2):473-80. PubMed PMID: 2387891. 3: Ho BT, Tansey LW, Engineer MS, Newman RA, Siddik ZH, Field WS, Krakoff IH. Beta-adrenoceptor binding studies with LY195448 and metabolites. Res Commun Chem Pathol Pharmacol. 1990 Jan;67(1):143-6. PubMed PMID: 2158135. 4: Ho DH, Covington WP, Lin J, Brown NS, Newman RA. Metabolism and disposition of (R)-4-[3-(2-hydroxy-2-phenyl)ethylamino-3-methylbutyl]benzamide Hcl (LY 195448) in rodents. Res Commun Chem Pathol Pharmacol. 1989 Nov;66(2):255-67. PubMed PMID: 2602657. 5: Cassidy J, Lewis C, Adams L, Setanoians A, Bayssas M, Boder GG, Rankin EM, Kaye SB. Phase I clinical and pharmacokinetic study of LY 195448. Cancer Chemother Pharmacol. 1989;24(4):233-7. PubMed PMID: 2752504.