Synonym
LY 164846; LY164846; LY-164846; 7-Bgmcc.
IUPAC/Chemical Name
7-((Aminobenzo(b)thien-3-ylacetyl)amino)-3-methyl-3-cephem-4-carboxylic acid
InChi Key
UZIXWKQHCIOPLV-FVKWTLKZSA-N
InChi Code
InChI=1S/C18H17N3O4S2/c1-8-6-27-17-13(16(23)21(17)14(8)18(24)25)20-15(22)12(19)10-7-26-11-5-3-2-4-9(10)11/h2-5,7,12-13,17H,6,19H2,1H3,(H,20,22)(H,24,25)/t12?,13?,17-/m0/s1
SMILES Code
O=C1C(NC(C(N)C2=CSC3=CC=CC=C32)=O)[C@]4([H])SCC(C)=C(C(O)=O)N14
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
403.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sassine-Nawas G, Baker CN, Thornsberry C. Antimicrobial activity of LY164846, a new oral cephalosporin, and recommendations for disk diffusion tests. Diagn Microbiol Infect Dis. 1987 Jan;6(1):41-8. PubMed PMID: 3100126.
2: Jorgensen JH, Redding JS, Howell AW. Comparative activities of LY 164846 and other orally administered beta-lactam antibiotics against Haemophilus influenzae. Antimicrob Agents Chemother. 1986 Jun;29(6):1090-1. PubMed PMID: 3488021; PubMed Central PMCID: PMC180505.
3: Lauderdale BL, Yu PK, Washington JA 2nd. In vitro activity of an orally administered cephalosporin, LY164846, against potentially pathogenic respiratory and dermal bacterial isolates. Antimicrob Agents Chemother. 1986 Apr;29(4):560-4. PubMed PMID: 3486628; PubMed Central PMCID: PMC180441.
4: Jones RN, Baker C, Barry AL, Fuchs PC. LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks. Antimicrob Agents Chemother. 1986 Mar;29(3):530-4. PubMed PMID: 3755018; PubMed Central PMCID: PMC180430.
5: Kukolja S, Pfeil JL, Draheim SE, Ott JL. Orally absorbable cephalosporin antibiotics. 3. Preparation of biologically active R isomer of 7-(3-benzothienylglycylamido)deacetoxycephalosporanic acid. J Med Chem. 1985 Dec;28(12):1903-6. PubMed PMID: 2933520.
6: Kukolja S, Draheim SE, Pfeil JL, Cooper RD, Graves BJ, Holmes RE, Neel DA, Huffman GW, Webber JA, Kinnick MD, et al. Orally absorbable cephalosporin antibiotics. 1. Structure-activity relationships of benzothienyl- and naphthylglycine derivatives of 7-aminodeacetoxycephalosporanic acid. J Med Chem. 1985 Dec;28(12):1886-96. PubMed PMID: 2933519.
