PD 117588 is a new quinolone against bacterial isolates from cancer patients. PD 117558 was found to have a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus faecalis and Group JK-corynebacteria). It was also extremely active against Gram-negative bacilli with the exception of Pseudomonas aeruginosa against which ciprofloxacin was more active. PD 117558 also had lower minimal inhibitory concentrations for most organisms tested than either imipenem or ceftazidime.
MedKoo Cat#: 525824
Name: PD 117588
CAS#: 99734-97-1
Chemical Formula: C20H23F2N3O3
Exact Mass: 391.1707
Molecular Weight: 391.41
Elemental Analysis: C, 61.37; H, 5.92; F, 9.71; N, 10.74; O, 12.26
The following data is based on the product molecular weight 391.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
