MedKoo Cat#: 525821 | Name: PD 116152

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 116152 is a new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. It is a novel phenazine antitumor antibiotic. The antibiotic is selectively active versus the bacterium Streptococcus pneumoniae (MIC less than 0.46 microgram/ml); the antitumor activity versus murine P388 leukemia is T/C 149.

Chemical Structure

PD 116152
PD 116152
CAS#101708-64-9

Theoretical Analysis

MedKoo Cat#: 525821

Name: PD 116152

CAS#: 101708-64-9

Chemical Formula: C16H12N2O6

Exact Mass: 328.0695

Molecular Weight: 328.28

Elemental Analysis: C, 58.54; H, 3.68; N, 8.53; O, 29.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
PD-116,152; PD116,152; PD 116,152; PD116152; PD-116152; PD 116152; NSC 373235.
IUPAC/Chemical Name
methyl 6-formyl-4,7,9-trihydroxy-8-methylphenazine-1-carboxylate
InChi Key
RZKNRCBVLASAPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12N2O6/c1-6-14(21)8(5-19)11-13(15(6)22)18-10-7(16(23)24-2)3-4-9(20)12(10)17-11/h3-5,20-22H,1-2H3
SMILES Code
O=C(C1=CC=C(O)C2=NC3=C(C=O)C(O)=C(C)C(O)=C3N=C21)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Smitka TA, Bunge RH, Wilton JH, Hokanson GC, French JC, He CH, Clardy J. PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity. J Antibiot (Tokyo). 1986 Jun;39(6):800-3. PubMed PMID: 3755428. 2: Tunac JB, Mamber SW, Graham BD, Dobson WE. PD 116,152, a novel phenazine antitumor antibiotic. Discovery, fermentation, culture characterization and biological activity. J Antibiot (Tokyo). 1986 Feb;39(2):192-7. PubMed PMID: 3754252.