Levoprotiline hydrochloride | CAS#76496-69-0

MedKoo Cat#: 525440 | Name: Levoprotiline hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Levoprotiline hydrochloride is a new antidepressant.

Chemical Structure

Levoprotiline hydrochloride

CAS#76496-69-0

Theoretical Analysis

MedKoo Cat#: 525440

Name: Levoprotiline hydrochloride

CAS#: 76496-69-0

Chemical Formula: C20H24ClNO

Exact Mass:

Molecular Weight: 329.87

Elemental Analysis: C, 72.82; H, 7.33; Cl, 10.75; N, 4.25; O, 4.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Levoprotiline hydrochloride; Levoprotiline HCl; CGP 12103 A; CGP-12 103 A.

IUPAC/Chemical Name

9,10-Ethanoanthracene-9(10H)-ethanol, alpha-((methylamino)methyl)-, hydrochloride, (R)-

InChi Key

MUOSVLIKDZRWMP-DQBGKMJDSA-N

InChi Code

InChI=1S/C20H23NO.ClH/c1-21-13-14(22)12-20-11-10-15(16-6-2-4-8-18(16)20)17-7-3-5-9-19(17)20;/h2-9,14-15,21-22H,10-13H2,1H3;1H/t14-,15?,20?;/m1./s1

SMILES Code

O[C@@H](CNC)CC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Levoprotiline hydrochloride is a new antidepressant.

In vitro activity:

TBD

In vivo activity:

The effects of repeated administration of levoprotiline, a novel type of tetracyclic antidepressant on histamine H1, muscarinic acetylcholine and alpha 1-adrenergic receptors and the response of phosphoinositide hydrolysis (PI) stimulated by histamine in the cortex of the rat brain were investigated. This demonstrates that the repeated treatment with levoprotiline has prominent action on the regulation of histamine H1 receptors and PI response coupling to histamine H1 receptors in vivo. Reference: Jpn J Pharmacol. 1992 May;59(1):31-5. https://pubmed.ncbi.nlm.nih.gov/1324374/

Preparing Stock Solutions

The following data is based on the product molecular weight 329.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Noguchi S, Inukai T. Repeated treatment with levoprotiline, a novel antidepressant, up-regulates histamine H1 receptors and phosphoinositide hydrolysis response in vivo. Jpn J Pharmacol. 1992 May;59(1):31-5. doi: 10.1254/jjp.59.31. PMID: 1324374.

In vitro protocol:

TBD

In vivo protocol:

1: Noguchi S, Okada M, Inukai T. Pharmacological profile of the new antidepressant levoprotiline. Arzneimittelforschung. 1992 Jun;42(6):787-94. PubMed PMID: 1418032.