MedKoo Cat#: 525818 | Name: PD 113271

Description:

WARNING: This product is for research use only, not for human or veterinary use.

The novel fermentation products fostriecin and analogs PD 113,270 and PD 113,271 are structurally related polyene lactone phosphates that have antitumor activity in vitro and in vivo.

Chemical Structure

PD 113271
PD 113271
CAS#87860-38-6

Theoretical Analysis

MedKoo Cat#: 525818

Name: PD 113271

CAS#: 87860-38-6

Chemical Formula: C19H27O10P

Exact Mass: 446.1342

Molecular Weight: 446.39

Elemental Analysis: C, 51.12; H, 6.10; O, 35.84; P, 6.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Antibiotic CL 1565T; CL 1565T; PD-113,271; PD113271; PD 113271
IUPAC/Chemical Name
(1E,7E,9E,11E)-3,6,13-trihydroxy-1-(3-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-methyltrideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
InChi Key
JIAYUFWCNLGCTK-IGICQAMHSA-N
InChi Code
InChI=1S/C19H27O10P/c1-19(24,11-10-16-15(22)8-9-18(23)28-16)17(29-30(25,26)27)13-14(21)7-5-3-2-4-6-12-20/h2-11,14-17,20-22,24H,12-13H2,1H3,(H2,25,26,27)/b3-2+,6-4+,7-5+,11-10+
SMILES Code
O=C1C=CC(O)C(/C=C/C(C)(O)C(OP(O)(O)=O)CC(O)/C=C/C=C/C=C/CO)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F. Total synthesis and stereochemistry of the antitumor antibiotic PD 113,271. Org Lett. 2006 Nov 9;8(23):5307-10. Erratum in: Org Lett. 2007 Mar 15;9(6):1173-4. PubMed PMID: 17078704. 2: Mamber SW, Okasinski WG, Pinter CD, Tunac JB. Antimycotic effects of the novel antitumor agents fostriecin (CI-920), PD 113,270 and PD 113,271. J Antibiot (Tokyo). 1986 Oct;39(10):1467-72. PubMed PMID: 3781915. 3: Stampwala SS, Bunge RH, Hurley TR, Willmer NE, Brankiewicz AJ, Steinman CE, Smitka TA, French JC. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization. J Antibiot (Tokyo). 1983 Dec;36(12):1601-5. PubMed PMID: 6689324. 4: Tunac JB, Graham BD, Dobson WE. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J Antibiot (Tokyo). 1983 Dec;36(12):1595-600. PubMed PMID: 6689323.