Synonym
Antibiotic CL 1565T; CL 1565T; PD-113,271; PD113271; PD 113271
IUPAC/Chemical Name
(1E,7E,9E,11E)-3,6,13-trihydroxy-1-(3-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-methyltrideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
InChi Key
JIAYUFWCNLGCTK-IGICQAMHSA-N
InChi Code
InChI=1S/C19H27O10P/c1-19(24,11-10-16-15(22)8-9-18(23)28-16)17(29-30(25,26)27)13-14(21)7-5-3-2-4-6-12-20/h2-11,14-17,20-22,24H,12-13H2,1H3,(H2,25,26,27)/b3-2+,6-4+,7-5+,11-10+
SMILES Code
O=C1C=CC(O)C(/C=C/C(C)(O)C(OP(O)(O)=O)CC(O)/C=C/C=C/C=C/CO)O1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
446.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F. Total synthesis and stereochemistry of the antitumor antibiotic PD 113,271. Org Lett. 2006 Nov 9;8(23):5307-10. Erratum in: Org Lett. 2007 Mar 15;9(6):1173-4. PubMed PMID: 17078704.
2: Mamber SW, Okasinski WG, Pinter CD, Tunac JB. Antimycotic effects of the novel antitumor agents fostriecin (CI-920), PD 113,270 and PD 113,271. J Antibiot (Tokyo). 1986 Oct;39(10):1467-72. PubMed PMID: 3781915.
3: Stampwala SS, Bunge RH, Hurley TR, Willmer NE, Brankiewicz AJ, Steinman CE, Smitka TA, French JC. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization. J Antibiot (Tokyo). 1983 Dec;36(12):1601-5. PubMed PMID: 6689324.
4: Tunac JB, Graham BD, Dobson WE. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J Antibiot (Tokyo). 1983 Dec;36(12):1595-600. PubMed PMID: 6689323.