JNJ-40355003 | CAS#1394894-41-7 | FAAH Inhibitor

MedKoo Cat#: 525403 | Name: JNJ-40355003

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-40355003 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 elevates the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey.

Chemical Structure

JNJ-40355003

CAS#1394894-41-7

Theoretical Analysis

MedKoo Cat#: 525403

Name: JNJ-40355003

CAS#: 1394894-41-7

Chemical Formula: C23H23ClN4O2

Exact Mass: 422.1510

Molecular Weight: 422.91

Elemental Analysis: C, 65.32; H, 5.48; Cl, 8.38; N, 13.25; O, 7.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

JNJ-40355003; JNJ 40355003; JNJ40355003.

IUPAC/Chemical Name

1-Piperazinecarboxamide, 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-

InChi Key

CTYVKSQPMCSUOR-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29)

SMILES Code

O=C(N1CCN(CC2=CC=CC(OC3=CC=C(Cl)C=C3)=C2)CC1)NC4=CC=CN=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 422.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Keith JM, Apodaca R, Tichenor M, Xiao W, Jones W, Pierce J, Seierstad M, Palmer J, Webb M, Karbarz M, Scott B, Wilson S, Luo L, Wennerholm M, Chang L, Brown S, Rizzolio M, Rynberg R, Chaplan S, Breitenbucher JG. Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate. ACS Med Chem Lett. 2012 Aug 22;3(10):823-7. doi: 10.1021/ml300186g. eCollection 2012 Oct 11. PubMed PMID: 24900385; PubMed Central PMCID: PMC4025847.