JNJ-17029259 | CAS#314267-57-7 | VEGF-R2 Inhibitor

MedKoo Cat#: 525306 | Name: JNJ-17029259

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-17029259 is an orally selective, nanomolar inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2). JNJ-17029259 blocks VEGF-stimulated mitogen-activated protein kinase signaling, proliferation/migration, and VEGF-R2 phosphorylation in human endothelial cells.

Chemical Structure

JNJ-17029259

CAS#314267-57-7

Theoretical Analysis

MedKoo Cat#: 525306

Name: JNJ-17029259

CAS#: 314267-57-7

Chemical Formula: C26H30N6O

Exact Mass: 442.2481

Molecular Weight: 442.56

Elemental Analysis: C, 70.56; H, 6.83; N, 18.99; O, 3.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

JNJ-17029259; JNJ 17029259; JNJ17029259.

IUPAC/Chemical Name

5-Pyrimidinecarbonitrile, 4-(4-(1-amino-1-methylethyl)phenyl)-2-((4-(2-(4-morpholinyl)ethyl)phenyl)amino)-

InChi Key

MROGTPNQSHMKIG-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H30N6O/c1-26(2,28)22-7-5-20(6-8-22)24-21(17-27)18-29-25(31-24)30-23-9-3-19(4-10-23)11-12-32-13-15-33-16-14-32/h3-10,18H,11-16,28H2,1-2H3,(H,29,30,31)

SMILES Code

N#CC1=CN=C(NC2=CC=C(CCN3CCOCC3)C=C2)N=C1C4=CC=C(C(C)(N)C)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 442.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Reuman M, Beish S, Davis J, Batchelor MJ, Hutchings MC, Moffat DF, Connolly PJ, Russell RK. Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasound-mediated addition of MeLi-CeCl3 to a nitrile. J Org Chem. 2008 Feb 1;73(3):1121-3. doi: 10.1021/jo7021372. Epub 2008 Jan 3. PubMed PMID: 18171079. 2: Emanuel S, Gruninger RH, Fuentes-Pesquera A, Connolly PJ, Seamon JA, Hazel S, Tominovich R, Hollister B, Napier C, D'Andrea MR, Reuman M, Bignan G, Tuman R, Johnson D, Moffatt D, Batchelor M, Foley A, O'Connell J, Allen R, Perry M, Jolliffe L, Middleton SA. A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models. Mol Pharmacol. 2004 Sep;66(3):635-47. PubMed PMID: 15322256.