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MedKoo Cat#: 326775 | Name: Loxapine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Loxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class and structurally related to clozapine (which belongs to the chemically akin class of dibenzodiazepines). Several researchers have argued that loxapine may behave as an atypical antipsychotic. Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant.

Chemical Structure

Loxapine
Loxapine
CAS#1977-10-2

Theoretical Analysis

MedKoo Cat#: 326775

Name: Loxapine

CAS#: 1977-10-2

Chemical Formula: C18H18ClN3O

Exact Mass: 327.1138

Molecular Weight: 327.81

Elemental Analysis: C, 65.95; H, 5.53; Cl, 10.81; N, 12.82; O, 4.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Adasuve; AZ-004; CL 62,362; CL 62362; CL-62362; Cloxazepine; Dibenzacepin; Dibenzoazepine; HF 3170; HF3170; Loxapine; Loxitane; Loxitane; LW 3170; Oxilapine; S 805; S-805; Staccato; loxapine; SUM 3170.
IUPAC/Chemical Name
2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
InChi Key
XJGVXQDUIWGIRW-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
SMILES Code
CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 327.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Siwek M. [Inhaled loxapine: A novel treatment for agitation in psychotic disorders]. Psychiatr Pol. 2014 Sep-Oct;48(5):917-30. Review. Polish. PubMed PMID: 25639013. 2: Inhaled loxapine (Adasuve) for acute agitation. Med Lett Drugs Ther. 2014 Apr 14;56(1440):31-2. Review. PubMed PMID: 24736249. 3: Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27(6):479-89. doi: 10.1007/s40263-013-0075-9. Review. PubMed PMID: 23740380. 4: Currier G, Walsh P. Safety and efficacy review of inhaled loxapine for treatment of agitation. Clin Schizophr Relat Psychoses. 2013 Apr;7(1):25-32. doi: 10.3371/CSRP.CUWA.032513. Review. PubMed PMID: 23538290. 5: Citrome L. Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder. Int J Clin Pract. 2012 Mar;66(3):318-25. doi: 10.1111/j.1742-1241.2011.02890.x. Epub 2012 Jan 9. Review. PubMed PMID: 22226343. 6: Citrome L. Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder. Int J Clin Pract. 2011 Mar;65(3):330-40. doi: 10.1111/j.1742-1241.2010.02615.x. Epub 2010 Dec 29. Review. PubMed PMID: 21199198. 7: Chakrabarti A, Bagnall A, Chue P, Fenton M, Palaniswamy V, Wong W, Xia J. Loxapine for schizophrenia. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD001943. Review. PubMed PMID: 17943763. 8: Mazzola CD, Miron S, Jenkins AJ. Loxapine intoxication: case report and literature review. J Anal Toxicol. 2000 Oct;24(7):638-41. Review. PubMed PMID: 11043672. 9: Fenton M, Murphy B, Wood J, Bagnall A, Chue P, Leitner M. Loxapine for schizophrenia. Cochrane Database Syst Rev. 2000;(2):CD001943. Review. Update in: Cochrane Database Syst Rev. 2007;(4):CD001943. PubMed PMID: 10796455. 10: Glazer WM. Does loxapine have "atypical" properties? Clinical evidence. J Clin Psychiatry. 1999;60 Suppl 10:42-6. Review. PubMed PMID: 10340686. 11: Collins DM, Gidal BE, Pitterle ME. Potential interaction between carbamazepine and loxapine: case report and retrospective review. Ann Pharmacother. 1993 Oct;27(10):1180-7. Review. PubMed PMID: 8251682. 12: Clozapine and loxapine for schizophrenia. Drug Ther Bull. 1991 May 28;29(11):41-2. Review. Erratum in: Drug Ther Bull 1991 Jun 24;29(13):52. PubMed PMID: 1747161. 13: Zisook S, Click MA Jr. Evaluations of loxapine succinate in the ambulatory treatment of acute schizophrenic episodes. Int Pharmacopsychiatry. 1980;15(6):365-78. Review. PubMed PMID: 7028656. 14: Heel RC, Brogden RN, Speight TM, Avery GS. Loxapine: a review of its pharmacological properties and therapeutic efficacy as an antipsychotic agent. Drugs. 1978 Mar;15(3):198-217. Review. PubMed PMID: 25167. 15: Ayd FJ Jr. Loxapine update: 1966-1976. Dis Nerv Syst. 1977 Nov;38(11):883-7. Review. PubMed PMID: 410614.