JNJ-10258859 is a novel, potent, and selective phosphodiesterase type 5 inhibitor. JNJ-10258859 inhibits phosphodiesterase type 5 with a K(i) of 0.23 nM and displayed excellent selectivity versus phosphodiesterase types 1-4 (>/=22,000 fold compared to phosphodiesterase type 5). JNJ-10258859 could be a useful treatment for erectile dysfunction.
MedKoo Cat#: 525299
Name: JNJ-10258859
CAS#: 374927-03-4
Chemical Formula: C30H24N4O3
Exact Mass: 488.1848
Molecular Weight: 488.54
Elemental Analysis: C, 73.76; H, 4.95; N, 11.47; O, 9.82
The following data is based on the product molecular weight 488.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
