VU0364439 is a selective positive allosteric modulator of mGlu5, enhancing receptor activity without direct activation. It is used in research on cognitive dysfunction and schizophrenia, modulating glutamatergic signaling. Studies suggest it improves synaptic plasticity, making it a useful tool for exploring mGlu5-related mechanisms.
MedKoo Cat#: 526782
Name: VU0364439
CAS#: 1246086-78-1
Chemical Formula: C18H13Cl2N3O3S
Exact Mass: 421.0055
Molecular Weight: 422.28
Elemental Analysis: C, 51.20; H, 3.10; Cl, 16.79; N, 9.95; O, 11.37; S, 7.59
The following data is based on the product molecular weight 422.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
