ICI 198615 | CAS#104448-53-5

MedKoo Cat#: 525263 | Name: ICI 198615

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI 198615 is a novel, potent and selective peptide leukotriene antagonist. ICI 198,615 may be useful for the the treatment of allergic diseases.

Chemical Structure

ICI 198615

CAS#104448-53-5

Theoretical Analysis

MedKoo Cat#: 525263

Name: ICI 198615

CAS#: 104448-53-5

Chemical Formula: C28H28N4O6S

Exact Mass: 548.1730

Molecular Weight: 548.61

Elemental Analysis: C, 61.30; H, 5.14; N, 10.21; O, 17.50; S, 5.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ICI 198615; ICI-198615; ICI198615; ICI-198,615; ZM 198615; ZM-198615.

IUPAC/Chemical Name

(1-((2-Methoxy-4-(((phenylsulfonyl)amino)carbonyl)phenyl)methyl)-1H-indazol-6-yl)carbamic acid cyclopentyl ester

InChi Key

YRCPIXCRSAKRGM-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H28N4O6S/c1-37-26-15-19(27(33)31-39(35,36)24-9-3-2-4-10-24)11-12-21(26)18-32-25-16-22(14-13-20(25)17-29-32)30-28(34)38-23-7-5-6-8-23/h2-4,9-17,23H,5-8,18H2,1H3,(H,30,34)(H,31,33)

SMILES Code

O=C(OC1CCCC1)NC2=CC3=C(C=C2)C=NN3CC4=CC=C(C(NS(=O)(C5=CC=CC=C5)=O)=O)C=C4OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 548.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Uchida Y, Hamada M, Kameyama M, Ohse H, Nomura A, Hasegawa S, Hirata F. ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Biochem Biophys Res Commun. 1992 Mar 31;183(3):1197-202. PubMed PMID: 1567397. 2: Smith EF 3rd, Slivjak MJ. ICI 198615 is an antagonist of leukotriene C4, leukotriene D4 and leukotriene E4 vasopressor responses in the conscious rat. Pharmacology. 1990;41(2):57-66. PubMed PMID: 2175920.