SCH 563705 | CAS#473728-58-4 | CXCR2/CXCR1 antagonist

MedKoo Cat#: 526767 | Name: SCH-563705

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SCH 563705 is a CXCR2/CXCR1 antagonist. SCH563705 selectively reduced the peripheral blood neutrophil frequency, and caused an elevation in the CXCR2 ligand CXCL1. SCH-563705 may have therapeutic potential for targeting CXCR2/CXCR1 in human arthritides.

Chemical Structure

SCH-563705

CAS#473728-58-4

Theoretical Analysis

MedKoo Cat#: 526767

Name: SCH-563705

CAS#: 473728-58-4

Chemical Formula: C23H27N3O5

Exact Mass: 425.1951

Molecular Weight: 425.49

Elemental Analysis: C, 64.93; H, 6.40; N, 9.88; O, 18.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SCH-563705; SCH 563705; SCH563705.

IUPAC/Chemical Name

CC(C1=COC([C@H](NC2=C(C(C2=O)=O)NC3=CC=CC(C(N(C)C)=O)=C3O)CC)=C1)C

InChi Key

InChi Code

SMILES Code

CC(C)C1C=C(OC=1)[C@@H](CC)NC2=C(NC3C(O)=C(C=CC=3)C(=O)N(C)C)C(=O)C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 425.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Min SH, Wang Y, Gonsiorek W, Anilkumar G, Kozlowski J, Lundell D, Fine JS, Grant EP. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6. doi: 10.1016/j.bbrc.2009.12.025. Epub 2009 Dec 14. PubMed PMID: 20004647.