Synonym
GSK-215083; GSK 215083; GSK215083;
IUPAC/Chemical Name
Quinoline, 3-((3-fluorophenyl)sulfonyl)-8-(4-methyl-1-piperazinyl)-
InChi Key
PXVJEDOZGDZJQY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20FN3O2S/c1-23-8-10-24(11-9-23)19-7-2-4-15-12-18(14-22-20(15)19)27(25,26)17-6-3-5-16(21)13-17/h2-7,12-14H,8-11H2,1H3
SMILES Code
CN1CCN(C2=C3N=CC(S(=O)(C4=CC=CC(F)=C4)=O)=CC3=CC=C2)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
385.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Becker G, Colomb J, Sgambato-Faure V, Tremblay L, Billard T, Zimmer L. Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):495-502. doi: 10.1007/s00259-014-2936-y. Epub 2014 Oct 21. PubMed PMID: 25331460.
3: Chopra A. [(11)C]-[N-Methyl]3-[(3-fluorophenyl)sulfonyl]-8-(4-methyl-1-piperazinyl)quinolin e. 2012 Feb 06 [updated 2012 Apr 27]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK92499/ PubMed PMID: 22553893.
4: Parker CA, Gunn RN, Rabiner EA, Slifstein M, Comley R, Salinas C, Johnson CN, Jakobsen S, Houle S, Laruelle M, Cunningham VJ, Martarello L. Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor. J Nucl Med. 2012 Feb;53(2):295-303. doi: 10.2967/jnumed.111.093419. Epub 2012 Jan 5. PubMed PMID: 22223878.
5: Comley RA, Salinas C, Mizrahi R, Vitcu I, Ng A, Hallett W, Keat N, Wilson AA, Rabiner EA, Laruelle M, Houle S. Biodistribution and radiation dosimetry of the serotonin 5-HT₆ ligand [¹¹C]GSK215083 determined from human whole-body PET. Mol Imaging Biol. 2012 Aug;14(4):517-21. doi: 10.1007/s11307-011-0523-1. PubMed PMID: 22076076.
6: Hirano K, Searle KL, Nasir S, Aw CC, Browne ER, Rutter AR. In vivo 5-HT(6) receptor occupancy by antipsychotic drugs in the rat brain. Neurosci Lett. 2011 Oct 10;503(3):240-3. doi: 10.1016/j.neulet.2011.08.044. Epub 2011 Aug 27. PubMed PMID: 21896308.
