Nystatin is a polyene antifungal, the antibiotic complex containing three biologically active components: A1, A2, and A3. Nystatin is used to treat fungal infections of the skin, mouth, vagina, and intestinal tract. Fungal medicines will not work for colds, flu, or other viral infections. Nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage, acidification, and death of the fungus. Ergosterol is unique to fungi, so the drug does not have such catastrophic effects on animals or plants. However, many of the systemic/toxic effects of nystatin are attributable to its effect on human cells via binding to mammalian sterols, namely cholesterol. This is the effect that accounts for the nephrotoxicity observed when high serum levels of nystatin are achieved.
MedKoo Cat#: 326754
Name: Nystatin
CAS#: 1400-61-9
Chemical Formula: C47H75NO17
Exact Mass: 925.5035
Molecular Weight: 926.11
Elemental Analysis: C, 60.96; H, 8.16; N, 1.51; O, 29.37
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.0 | 54.00 |
The following data is based on the product molecular weight 926.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
