GSK 1440115 | CAS#1003878-16-7 | urotensin II receptor antagonist

MedKoo Cat#: 525178 | Name: GSK 1440115

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK 1440115 is an orally active urotensin II receptor antagonist. GSK 1440115 is used for the treatment of asthma.

Chemical Structure

GSK 1440115

CAS#1003878-16-7

Theoretical Analysis

MedKoo Cat#: 525178

Name: GSK 1440115

CAS#: 1003878-16-7

Chemical Formula: C30H29Cl2N3O6

Exact Mass: 597.1433

Molecular Weight: 598.47

Elemental Analysis: C, 60.21; H, 4.88; Cl, 11.85; N, 7.02; O, 16.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK 1440115; GSK-1440115; GSK1440115.

IUPAC/Chemical Name

4'-(1-(((6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-diphenylcarboxylic acid

InChi Key

YNBJTYUXPHTSFF-SANMLTNESA-N

InChi Code

InChI=1S/C30H29Cl2N3O6/c1-33(28(36)17-35-25-14-23(31)24(32)15-27(25)41-18-29(35)37)26(16-34-10-12-40-13-11-34)21-6-2-19(3-7-21)20-4-8-22(9-5-20)30(38)39/h2-9,14-15,26H,10-13,16-18H2,1H3,(H,38,39)/t26-/m0/s1

SMILES Code

O=C(C1=CC=C(C2=CC=C([C@@H](N(C(CN3C(COC4=CC(Cl)=C(Cl)C=C34)=O)=O)C)CN5CCOCC5)C=C2)C=C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 598.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Behm DJ, Aiyar NV, Olzinski AR, McAtee JJ, Hilfiker MA, Dodson JW, Dowdell SE, Wang GZ, Goodman KB, Sehon CA, Harpel MR, Willette RN, Neeb MJ, Leach CA, Douglas SA. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br J Pharmacol. 2010 Sep;161(1):207-28. doi: 10.1111/j.1476-5381.2010.00889.x. PubMed PMID: 20718751; PubMed Central PMCID: PMC2962828.