MedKoo Cat#: 525176 | Name: GS 389

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GS 389 is a novel tetrahydroisoquinoline analog. GS-389 significantly increased cGMP levels in the rat aorta and inhibited cGMP phosphodiesterase from the rabbit brain. It has vasorelaxant properties.

Chemical Structure

GS 389
GS 389
CAS#41498-37-7

Theoretical Analysis

MedKoo Cat#: 525176

Name: GS 389

CAS#: 41498-37-7

Chemical Formula: C19H23NO3

Exact Mass: 313.1678

Molecular Weight: 313.39

Elemental Analysis: C, 72.82; H, 7.40; N, 4.47; O, 15.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GS 389; GS-389; GS389.
IUPAC/Chemical Name
1-(4'-Methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
InChi Key
GXTUEUWFEKEQHJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-7,11-12,17,20H,8-10H2,1-3H3
SMILES Code
COc1ccc(cc1)CC2c3cc(c(cc3CCN2)OC)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 313.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chang KC, Chong WS, Lee IJ. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994 Apr;72(4):327-34. PubMed PMID: 7922863. 2: Chang KC, Lim JK, Park CW. Pharmacological evaluation of GS-389, a novel tetrahydroisoquinoline analog related to higenamine, on vascular smooth muscle. Life Sci. 1992;51(1):67-74. PubMed PMID: 1614275.