FR-181157 | FR-181157 Free Base | CAS#171046-15-4 | 200433-03-0

MedKoo Cat#: 525109 | Name: FR-181157

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-181157 is a novel prostaglandin (PG) mimetic. FR181157 shows high potency and agonist efficacy at the IP receptor and has good bioavailability.

Chemical Structure

FR-181157

CAS#171046-15-4

Theoretical Analysis

MedKoo Cat#: 525109

Name: FR-181157

CAS#: 171046-15-4

Chemical Formula: C30H26NNaO4

Exact Mass:

Molecular Weight: 487.52

Elemental Analysis: C, 73.91; H, 5.38; N, 2.87; Na, 4.72; O, 13.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

171046-15-4 (FR-181157) ; 200433-03-0 (FR-181157 Free Base)

Synonym

FR-181157; FR 181157; FR181157; FR-181157 Free Base.

IUPAC/Chemical Name

Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium salt

InChi Key

DPECFBBZFTXROT-JIDHJSLPSA-M

InChi Code

InChI=1S/C30H27NO4.Na/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23;/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33);/q;+1/p-1/t24-;/m0./s1

SMILES Code

c1ccc(cc1)c2c(oc(n2)C3=CCCC[C@H]3Cc4cccc(c4)OCC(=O)[O-])c5ccccc5.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 487.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tanaka A, Hattori K, Taniguchi K, Okitsu O, Tabuchi S, Nishio M, Nagakura Y, Maeda N, Murai H, Seki J. Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4861-4. Epub 2006 Jul 11. PubMed PMID: 16837197. 2: Hattori K, Takamura F, Tanaka A, Takasugi H, Taniguchi K, Nishio M, Koyama S, Seki J, Sakane K. Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3284-7. PubMed PMID: 15935659. 3: Hattori K, Tabuchi S, Okitsu O, Taniguchi K. A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4277-9. PubMed PMID: 14643308.