Synonym
FR-198248; FR-198248; FR-198248.
IUPAC/Chemical Name
1,5,6,7-Isobenzofurantetrol, 1,3-dihydro-4-methyl-
InChi Key
KTLUDVLHAZMWIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10O5/c1-4-5(2-10)6(3-11)8(13)9(14)7(4)12/h3,10,12-14H,2H2,1H3
SMILES Code
Cc1c(O)c(O)c(O)c(C=O)c1CO
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
198.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kwon YJ, Zheng CJ, Kim WG. Isolation and identification of FR198248, a hydroxylated 1,3-dihydroisobenzofuran, from Aspergillus flavipes as an inhibitor of peptide deformylase. Biosci Biotechnol Biochem. 2010;74(2):390-3. Epub 2010 Feb 7. PubMed PMID: 20139618.
2: Nishihara Y, Takase S, Tsujii E, Hatanaka H, Hashimoto S. New anti-influenza agents, FR198248 and its derivatives. II. Characterization of FR198248, its related compounds and some derivatives. J Antibiot (Tokyo). 2001 Mar;54(3):297-303. PubMed PMID: 11372786.
3: Nishihara Y, Tsujii E, Yamagishi Y, Sakamoto K, Tsurumi Y, Furukawa S, Ohtsu R, Kino T, Hino M, Yamashita M, Hashimoto S. FR198248, a new anti-influenza agent isolated from Apsergillus terreus No 13830. I. Taxomony, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 2001 Feb;54(2):136-43. PubMed PMID: 11302485.
