Synonym
ML-281; ML-281; ML281.
IUPAC/Chemical Name
N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
InChi Key
HWOYIOLMBQSTQS-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H19N3O2S/c1-13(2)14-9-10-16(24-21(26)19-8-5-11-28-19)15(12-14)20-22(27)25-18-7-4-3-6-17(18)23-20/h3-13H,1-2H3,(H,24,26)(H,25,27)
SMILES Code
O=C(C1=CC=CS1)NC2=CC=C(C(C)C)C=C2C3=NC4=C(C=CC=C4)NC3=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO, not in water |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
389.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, Silkworth W,
Dandapani S, Munoz B, Palmer M, Scherer C, Schreiber SL. Screen for Inhibitors of
STK33 Kinase Activity. 2011 Dec 16 [updated 2014 May 13]. Probe Reports from the
NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for
Biotechnology Information (US); 2010-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK133418/
PubMed PMID: 23658944.
2: Weïwer M, Spoonamore J, Wei J, Guichard B, Ross NT, Masson K, Silkworth W,
Dandapani S, Palmer M, Scherer CA, Stern AM, Schreiber SL, Munoz B. A Potent and
Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality
in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub
2012 Oct 22. PubMed PMID: 23256033; PubMed Central PMCID: PMC3523537.
