Alectinib synthetic routes

CAT#: 562012 | Name: Voxilaprevir | CAS# 1535212-07-7

Purchases for research

Description:

Voxilaprevir is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synthetic Routes

Voxilaprevir - Synthetic Route 1

Voxilaprevir - Synthetic Route 1

Synthetic reference

Cagulada, Amy; Chan, Johann; Chan, Lina; Colby, Denise A.; Karki, Kapil Kumar; Kato, Darryl; Keaton, Katie Ann; Kondapally, Sudha; Levins, Chris; Littke, Adam; Martinez, Ruben; Pcion, Dominika; Reynolds, Troy; Ross, Bruce; Sangi, Michael; Schrier, Adam J.; Seng, Pamela; Siegel, Dustin; Shapiro, Nathan; Tang, Donald; Taylor, James G.; Tripp, Jonathan; Waltman, Andrew W.; Yu, Lawrence. Synthesis of an antiviral N-(3-ethyl)prolyl-1-aminocyclopropanecarboxylic acid peptide and new routes to its difluoromethylaminocyclopropanecarboxylic acid intermediate. Assignee Gilead Sciences, Inc., USA. US 20150175626. (2015).

Voxilaprevir - Synthetic Route 2

Voxilaprevir - Synthetic Route 2

Synthetic reference

Bringley, Dustin; Chan, Johann; Fung, Peter; Keaton, Katie; Lapina, Olga; Morrison, Henry; Pcion, Dominika. Crystalline forms of an antiviral N-(3-ethyl)prolyl-1-aminocyclopropanecarboxylic acid peptide. Assignee Gilead Sciences, Inc., USA. US 20150175625. (2015).

Voxilaprevir - Synthetic Route 3

Voxilaprevir - Synthetic Route 3

Synthetic reference

Bjornson, Kyla; Canales, Eda; Cottell, Jeromy J.; Karki, Kapil Kumar; Katana, Ashley Anne; Kato, Darryl; Kobayashi, Tetsuya; Link, John O.; Martinez, Ruben; Phillips, Barton W.; Pyun, Hyung-Jung; Sangi, Michael; Schrier, Adam James; Siegel, Dustin; Taylor, James G.; Tran, Chinh Viet; Trejo Martin, Teresa Alejandra; Vivian, Randall W.; Yang, Zheng-Yu; Zablocki, Jeff; Zipfel, Sheila. Preparation of N-(3-alkyl- and 3-carbocyclyl)prolyl-1-aminocyclopropanecarboxylic acid peptides as inhibitors of hepatitis C virus. Assignee Gilead Sciences, Inc., USA. WO 2014008285. 2014).