Alectinib synthetic routes

CAT#: 318970 | Name: Valsartan | CAS# 137862-53-4

Purchases for research

Description:

Valsartan is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack.

Synthetic Routes

Valsartan - Synthetic Route 1

Valsartan - Synthetic Route 1

Synthetic reference

Seki, Masahiko; Nagahama, Masaki. Synthesis of Angiotensin II Receptor Blockers by Means of a Catalytic System for C-H Activation. Journal of Organic Chemistry. Volume 76. Issue 24. Pages 10198-10206. Journal; Online Computer File. (2011)

Valsartan - Synthetic Route 2

Valsartan - Synthetic Route 2

Synthetic reference

Goossen, Lukas J.; Melzer, Bettina. Synthesis of Valsartan via Decarboxylative Biaryl Coupling. Journal of Organic Chemistry. Volume 72. Issue 19. Pages 7473-7476. Journal. (2007)

Valsartan - Synthetic Route 3

Valsartan - Synthetic Route 3

Synthetic reference

Nagaki, Aiichiro; Hirose, Katsuyuki; Tonomura, Osamu; Taniguchi, Satoshi; Taga, Toshiki; Hasebe, Shinji; Ishizuka, Norio; Yoshida, Jun-ichi. Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsartan. Organic Process Research & Development. Volume 20. Issue 3. Pages 687-691. Journal; Online Computer File. (2016)

Valsartan - Synthetic Route 4

Valsartan - Synthetic Route 4

Synthetic reference

Ghosh, Samir; Kumar, A. Sanjeev; Mehta, G. N. Convenient synthesis of Valsartan via a Suzuki reaction. Journal of Chemical Research. Volume 34. Issue 4. Pages 191-193. Journal. (2010)

Valsartan - Synthetic Route 5

Valsartan - Synthetic Route 5

Synthetic reference

Ambati, Srinivas; Penikelapati, Hanumantha Rao; Maruthikumar, T. V.; Ambati, Narahari Babu. Alternative synthesis of valsartan via Negishi coupling. Pharma Chemica. Volume 3. Issue 4. Pages 13-17. Journal; Online Computer File. (2011)

Valsartan - Synthetic Route 6

Valsartan - Synthetic Route 6

Synthetic reference

Gano, Kyle W. Preparation of pyrido[2,1-a]isoquinoline derivatives for treating hyperkinetic disorders. Assignee Neurocrine Biosciences, Inc., USA. WO 2008058261. (2008).

Valsartan - Synthetic Route 7

Valsartan - Synthetic Route 7

Synthetic reference

Chen, Liye; Ren, Peng; Carrow, Brad P. Tri(1-adamantyl)phosphine: Expanding the Boundary of Electron-Releasing Character Available to Organophosphorus Compounds. Journal of the American Chemical Society. Volume 138. Issue 20. Pages 6392-6395. 2016.

Valsartan - Synthetic Route 8

Valsartan - Synthetic Route 8

Synthetic reference

Sedelmeier, Gottfried. A preparation of tetrazole derivatives via heterocyclization of nitriles with azides. Assignee Novartis A.-G., Switz.; Novartis Pharma G.m.b.H. WO 2005014602 A1. (2005).

Valsartan - Synthetic Route 9

Valsartan - Synthetic Route 9

Synthetic reference

Zhang, Chen Xi; Zheng, Guo Jun; Bi, Fu Qiang; Li, Yu Lin. A simple and efficient synthesis of the valsartan. Chinese Chemical Letters. Volume 19. Issue 7. Pages 759-761. 2008.