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Alectinib synthetic routes

Aripiprazole Lauroxil - Synthetic Route

CAT#: 326728 | Name: Aripiprazole Lauroxil | CAS#

Purchases for research

Description:

Aripiprazole lauroxil, aslo known as RDC 3317, is a long-acting injectable atypical antipsychotic. It is an N-acyloxymethyl prodrug of aripiprazole that is administered via intramuscular injection once every four to six weeks for the treatment of schizophrenia. Aripiprazole lauroxil was approved by the U.S. FDA on 5 October 2015.

Synthetic Routes

Aripiprazole Lauroxil - Synthetic Route 1

Aripiprazole Lauroxil - Synthetic Route 1

Synthetic reference

Yin, Hongliu; Pan, Jie; Xiao, Peng. Preparation method of aripiprazole dodecanoate (Aristada) for treating schizophrenia. CN 107628999. (Assignee Suzhou Huajian Ruida Pharmaceutical Technology Co., Ltd., Peop. Rep. China)

Aripiprazole Lauroxil - Synthetic Route 2

Aripiprazole Lauroxil - Synthetic Route 2

Synthetic reference

Hickey, Migali B.; Vandiver, Jennifer. Aripiprazole formulations having increased injection speeds. WO 2015143145. (Assignee Alkermes Pharma Ireland Limited, Ire.)

Aripiprazole Lauroxil - Synthetic Route 3

Aripiprazole Lauroxil - Synthetic Route 3

Synthetic reference

Pomares Marco, Marta; Marquillas Olondriz, Francisco de Asis; Bessa Bellmunt, Jorge; De Leon Martin, Antonio Abelino . Process for the preparation of aripiprazole lauroxil (Assignee Interquim, S.A., Spain)

Aripiprazole Lauroxil - Synthetic Route 4

Aripiprazole Lauroxil - Synthetic Route 4

Synthetic reference

Thirumalai Rajan, Srinivasan; Eswaraiah, Sajja; Malleswara Reddy, Jakku. Improved process for the preparation of aripiprazole lauroxil (Assignee MSN Laboratories Private Limited, R&D Center, India; Venkata Panakala Rao, Gogulapati)

Aripiprazole Lauroxil - Synthetic Route 5

Aripiprazole Lauroxil - Synthetic Route 5

Synthetic reference

Gore, Vinayak; Joshi, Rajesh D.; Hublikar, Mahesh. Process for the preparation of aripiprazole lauroxil. (Assignee Mylan Laboratories Limited, India)

Aripiprazole Lauroxil - Synthetic Route 6

Aripiprazole Lauroxil - Synthetic Route 6

Synthetic reference

Perry, Jason M.; Deaver, Daniel R.; Hickey, Magali B.; Remenar, Julius F.; Vandiver, Jennifer; Palmieri, Michael J., Jr.; Pan, Zhengzheng. Pharmaceutical compositions of hydrolytically labile antipsychotic agents having improved storage stability. (Assignee Alkermes Pharma Ireland Limited, Ire)

Aripiprazole Lauroxil - Synthetic Route 7

Aripiprazole Lauroxil - Synthetic Route 7

Synthetic reference

Remenar, Julius F.; Blumberg, Laura Cook; Zeidan, Tarek A. Process for synthesizing oxidized lactam compounds. (Assignee Alkermes, Inc., USA)

Aripiprazole Lauroxil - Synthetic Route 8

Aripiprazole Lauroxil - Synthetic Route 8

Synthetic reference

Anon. A process for the preparation of aripiprazole lauroxil. IP.com Journal. Volume 18. Issue 8A. Pages 1-2. 2018.

Aripiprazole Lauroxil - Synthetic Route 9

Aripiprazole Lauroxil - Synthetic Route 9

Synthetic reference

Hsiao, Tsung-Yu; Huang, Yu-Hui. Process for preparing aripiprazole lauroxil and intermediates thereof from aripiprazole. Assignee Scinopharm Taiwan, Ltd., Taiwan. US 20180265472. 2018.

Aripiprazole Lauroxil - Synthetic Route 10

Aripiprazole Lauroxil - Synthetic Route 10

Synthetic reference

Ponnaiah, Ravi; Kumar, Neela Praveen; Guruswamy, Batthini; Pendem, Krishnaiah; Lakkadasu, Satya Nagendra Kumar; Gattikoppula, Mahesh. Improved process for the preparation of aripiprazole lauroxil. Assignee Neuland Pharma Research Private Limited, India. WO 2018109775. 2018.