Selexipag, also known as ACT-293987 and NS-304, is a a first-in-class orally available selective non-prostanoid IP receptor agonist, which is currently in development by Actelion as a treatment of pulmonary arterial hypertension. Selexipag and its active metabolite, ACT-333679, are agonists at the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation.
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Mathad, Vijayavitthal Thippannachar; Doddappa, Pralhad Anekal; Kardile, Pritesh Bhimraj; Padaki, Santhosh Ambadas; Gaikwad, Bapusaheb Shrihari; Shinde, Gorakshanath Balasaheb. Process for the preparation of selexipag and intermediates thereof. WO 2017042828. (Megafine Pharma (P) Ltd., India)
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