Plecanatide (brand name Trulance), is a drug approved by the FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.
Chen, Xue Ming; Zhu, Yan Ting; Mi, Peng Cheng; Tao, An Jin; Yuan, Jian Cheng. Preparation of plecanatide. WO 2018205401. (PCT Int. Appl. (2018))
Shailubhai, Kunwar; Comiskey, Stephen; Feng, Rong; Bai, Juncai; Zhang, Ruoping; Jia, Jun; Zhou, Junfeng; Zhao, Qiao; Zhang, Guoqing. Preparation of ultra-pure guanylate cyclase C agonist peptides by purification via solvent exchange-lyophilization. WO 2014197720. (PCT Int. Appl. (2014)).
Jacob, Gary S.; Shailubhai, Kunwar. Peptide agonists of guanylate cyclase receptors useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders. US 20140187470. (U.S. Pat. Appl. Publ. (2014))
Zhu, Yishen; Zhou, Yunlong; Wei, Ping; Ouyang, Pingkai. Process for preparation of plecanatide. Assignee Nanjing Tech University, Peop. Rep. China. CN 104628827 A (2015).
Zhu, Richeng; Mi, Pengcheng; Ma, Yaping; Yuan, Jiancheng. Process for preparation of plecanatide. Assignee Hybio Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103694320 A (2014).
Xu, Feng; Su, Jun; Gu, Haitao; Zhou, Jinyu; Liu, Biao; Sun, Meilu. Preparation of plecanatide by solid-phase peptide synthesis method. Assignee SINOPEP Jiangsu Inc., Peop. Rep. China. CN 108003222 A (2018).
