Pibrentasvir, also known as ABT-530, is a protease inhibitor potentially for the treatment of HCV infection.
Wagner R, Randolph JT, Patel SV, Nelson L, Matulenko MA, Keddy R, Pratt JK, Liu D, Krueger AC, Donner PL, Hutchinson DK, Flentge C, Betebenner D, Rockway T, Maring CJ, Ng TI, Krishnan P, Pilot-Matias T, Collins C, Panchal N, Reisch T, Dekhtyar T, Mondal R, Stolarik DF, Gao Y, Gao W, Beno DA, Kati WM. Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530). J Med Chem. 2018 May 10;61(9):4052-4066. doi: 10.1021/acs.jmedchem.8b00082. Epub 2018 Apr 23. PubMed PMID: 29653491.
DeGoey, David A.; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L.; Krueger, Allan C.; Randolph, John T.; Motter, Christopher E.; Nelson, Lissa T.; Patel, Sachel V.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Gao, Yi; Liu, Dachun; Pratt, John K.; Rockway, Todd W.; Maring, Clarence J.; Hutchinson, Douglas K.; Flentge, Charles A.; Wagner, Rolf; Tufano, Michael D.; Betebenner, David A.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Sebel H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel D.; Bellizzi, Mary E.; Carroll, William A. Heterocyclic peptide compounds as antiviral agents and their preparation and use in the treatment of hepatitis C virus infection. WO 2012051361. (Assignee Abbott Laboratories, USA)
Bellizzi, Mary E.; Betebenner, David A.; Califano, Jean-Christophe C.; Carroll, William A.; Caspi, Daniel D.; Degoey, David A.; Donner, Pamela L.; Flentge, Charles A.; Gao, Yi; Hutchins, Charles W.; Hutchinson, Douglas K.; Jinkerson, Tammie K.; Kati, Warren M.; Keddy, Ryan G.; Krueger, Allan C.; Li, Wenke; Liu, Dachun; Maring, Clarence J.; Matulenko, Mark A.; Motter, Christopher E.; Nelson, Lissa T.; Patel, Sachin V.; Pratt, John K.; Randolph, John T.; Rockway, Todd W.; Sarris, Kathy; Tufano, Michael D.; Wagaw, Seble H.; Wagner, Rolf; Woller, Kevin R. Heterocyclic peptide compounds as antiviral agents and their preparation and use in the treatment of hepatitis C virus infection. US 20170157104. (Assignee AbbVie Inc., USA)
Caspi, Daniel D.; Diwan, Moiz; Califano, Jean-Christophe C.; Mack, Daniel J.; Shekhar, Shashank. Development of an Operational Space Using Mechanistic Models for a Pd-Catalyzed Amidation Reaction Used in the Synthesis of ABT-530. Organic Process Research & Development. Volume 23. Issue 8. Pages 1509-1521. (2019).
