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Home  /  Drug Synthesis

Alectinib synthetic routes

Letermovir - Synthetic Route

CAT#: 319765 | Name: Letermovir | CAS#

Purchases for research

Description:

Letermovir, also known as MK-8828 and AIC-246, is an antiviral drug that is being developed for the treatment of cytomegalovirus (CVM) infections. Letermovir has been tested in CMV infected patients with allogeneic stem cell transplants and may also be useful for other patients with a compromised immune system such as those with organ transplants or HIV infections.

Synthetic Routes

Letermovir - Synthetic Route 1

Letermovir - Synthetic Route 1

Synthetic reference

Humphrey, Guy & M. Dalby, Stephen & Andreani, Teresa & Xiang, Bangping & R. Luzung, Michael & Jake Song, Zhiguo & Shevlin, Michael & Christensen, Melodie & Belyk, Kevin & M. Tschaen, David. (2016). Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction. Organic Process Research & Development. 20. 10.1021/acs.oprd.6b00076.

Letermovir - Synthetic Route 2

Letermovir - Synthetic Route 2

Synthetic reference

P.-S. Wang, M.-L. Shen, T.-C. Wang, H.-C. Lin, L.-Z. Gong, Angew. Chem. Int. Ed. 2017, 56, 16032.

Letermovir - Synthetic Route 3

Letermovir - Synthetic Route 3

Synthetic reference

Goossen, Kaethe; Kuhn, Oliver; Berwe, Mathias; Krueger, Joachim; Militzer, Hans-Christian. Process for preparation of dihydroquinazolineacetic acids via hydrolysis of the corresponding alkyl esters. WO 2006133822. (Assignee Bayer Healthcare A.-G., Germany)

Letermovir - Synthetic Route 4

Letermovir - Synthetic Route 4

Synthetic reference

Paulus, Kerstin; Schwab, Wilfried; Grunder, Dominique; Van Hoogevest, Peter. Pharmaceutical preparation containing an antivirally effective dihydroquinazoline derivative. WO 2013127970. (Assignee AiCuris GmbH & Co. KG, Germany)

Letermovir - Synthetic Route 5

Letermovir - Synthetic Route 5

Synthetic reference

Grunenberg, Alfons; Berwe, Mathias; Keil, Birgit; Aret, Edwin; Paulus, Kerstin; Schwab, Wilfried. Preparation of sodium and calcium salts of dihydroquinazoline derivatives useful in the prevention and/or treatment of viral infections. WO 2013127971. (Assignee AiCuris GmbH & Co. KG, Germany)

Letermovir - Synthetic Route 6

Letermovir - Synthetic Route 6

Synthetic reference

Luzung, Michael; Humphrey, Guy; Xiang, Bangping; Belyk, Kevin M.; Dalby, Stephen Mark; Schwab, Wilfried; Klenke, Burkhard; Moody, Tom; Brown, Gareth. Process for the preparation of substituted quinazoline compounds. WO 2015088931. (Assignee Merck Sharp & Dohme Corp., USA; AiCuris GmbH & Co. KG)

Letermovir - Synthetic Route 7

Letermovir - Synthetic Route 7

Synthetic reference

Zhang, Chengzhi; Chakma, Justin. Preparation of deuterated dihydroquinazoline inhibitors of viral terminase. WO 2016109360. (Assignee Auspex Pharmaceuticals, Inc., USA)

Letermovir - Synthetic Route 8

Letermovir - Synthetic Route 8

Synthetic reference

Chung, Cheol K.; Humphrey, Guy R.; Liu, Zhijian; McLaughlin, Mark; Xu, Yingju; Yu, Younong. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts. WO 2017091453. (Assignee Merck Sharp & Dohme Corp., USA)