Tedizolid phosphate, also know as TR-701FA tedizolid, torezolid (trade name Sivextro), is an oxazolidinone drug being developed by Cubist Pharmaceuticals following acquisition of Trius Therapeutics (originator: Dong-A Pharmaceuticals) for complicated skin and skin-structure infections (cSSSIs), including those caused by methicillin-resistant Staphylococcus aureus (MRSA). Tedizolid has been approved by the FDA on June 20, 2014, for the treatment of MRSA skin infections.
: Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa. Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. European Journal of Medicinal Chemistry. Volume 46. Issue 4. Pages 1027-1039. Journal. (2011).
: Chen, Jian; Liu, Zhenfeng; Ying, Shuhuan. Preparation of terdiazolamine phosphate. Assignee Shanghai Bozhi Yanxin Pharmaceutical Technology Co., Ltd., Peop. Rep. China. CN 110804038. (2020).
Huang, Zhiyan; Wang, Junya; Wang, Zuodi; Ren, Juan; Zhang, An; Xue, Dong; Yang, Jun; Liu, Jianbin. Method for synthesis of tedizolid phosphate under catalysis of nickel. Assignee Shaanxi Sier Biological Technology Co., Ltd., Peop. Rep. China; Shaanxi Normal University. CN 107827927. (2018).
Reddy, Srinivas Reddy Desi; Rane, Dnyandev Ragho; Velivela, Srinivas Rao; Buthukuri, Venkata Reddy. A novel process for the preparation of Tedizolid. Assignee Optimus Drugs (P) Ltd., India. IN 2014CH05297. (2016).
: Li, Siyuan; Gui, Shaoxiao; Zhang, Jicheng; Huang, Luning; Tao, Anping; Gu, Hong. Preparation method for tedizolid and its intermediate. Assignee Shanghai SynCores Technologies, Inc., Peop. Rep. China. CN 106632298. (2017).
: Xu, Xuenong. Green preparation method of tedizolid phosphate by coupling. Assignee Suzhou Miracpharma Technology Co., Ltd., Peop. Rep. China; Zheren Pharmaceutical Nanjing Co., Ltd. WO 2016058467. (2016).
Zhu, Yizhong; Zhang, Xiquan; Liu, Fei; Gu, Hongmei; Zhu, Bo; Tang, Jianqiu; Tang, Song; Wang, Lulu. Tedizolid phosphate, intermediate and preparation method thereof. Assignee Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Peop. Rep. China. CN 105418678. (2016).
Singh, Rakesh; Sharma, Atul; Khanna, Mahavir Singh; Prasad, Mohan. Processes for the preparation of tedizolid phosphate and its intermediates. Assignee Sun Pharmaceutical Industries Ltd., India. WO 2016088102. (2016).
Sud, Abhishek; Chaudhari, Pramod; Bandichhor, Rakeshwar; Dahanukar, Vilas Hareshwar; Cheemalapati, Venkata Annapurna Sasi Kala; Kavitapu, Dasameswara Rao; Lilakar, Jaydeepkumar Dahyabhai. Preparation of tedizolid phosphate. Assignee Dr. Reddy\'s Laboratories Limited, India. WO 2016009401. (2016).
Yuan, Jiandong; Chen, Yao; Hang, Wenming. Preparation of oxazolidinone compound and its intermediate. Assignee BrightGene Bio-Medical Technology (Suzhou) Co., Ltd., Peop. Rep. China; Xintai Pharmaceutical (Suzhou) Co., Ltd. CN 104496979. (2015).
