Tafluprost, also known as MK2452 and AFP-168, is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.
Syu, Jin-Fong; Wang, Yun-Ting; Liu, Kung-Cheng; Wu, Ping-Yu; Henschke, Julian P.; Wu, Hsyueh-Liang. Rh(I)-Catalyzed 1,4-Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins. Journal of Organic Chemistry. Volume 81. Issue 22. Pages 10832-10844. Journal; Online Computer File. (2016).
Matsumura, Yasushi; Nakano, Takashi; Mori, Nobuaki; Morizawa, Yoshitomi. Synthesis and biological properties of novel fluoroprostaglandin derivatives: highly selective and potent agonists for prostaglandin receptors. Chimia. Volume 58. Issue 3. Pages 148-152. Journal. (2004).
Wei, Shih-Yi; Yeh, Yu-Chih; Hsu, Min-Kuan; Kao, Li-Ta. Preparation of isomer-free prostaglandins and their intermediates. Assignee Chirogate International Inc., Taiwan. US 20170015646. (2017).
Lee, Hyo Seon; Song, Gyeong Heon; Shin, Hyeon Ik. Method for the preparation of tafluprost. Assignee Yonsung Fine Chemical Co., Ltd., S. Korea. KR 2016116402. (2016).
Yang, Bo; Peng, Yue. A process for preparing tafluprost. Assignee Tianze Enyuan (Tianjin) Pharmaceutical Technology Co., Ltd., Peop. Rep. China. CN 103804195. (2014).
Tsai, Chia-Chung; Chen, Chien-Yuh; Liang, Sen-Bau; Lo, Yu-Chi; Yao, Chi-Hsiang. Process for the purification of tafluprost and travoprost by removing fluorine containing impurity using preparative HPLC. Assignee Everlight USA, Inc., USA. US 20140051882. (2014).
Wen, Wen-Hsien. Process for preparation of tafluprost and intermediates thereof. Assignee ScinoPharm (Changshu) Pharmaceuticals, Ltd., Peop. Rep. China. WO 2014023256. (2014).
Jackson, Mark P. Preparation of pure prostaglandin analogs via prostaglandin analog amine salt intermediates. Assignee Dr. Reddy's Laboratories Limited, India. WO 2013118058. (2013).
Zhang, Jian; Wang, Runqing; Yu, Jianghui. Preparation method for high-purity Tafluprost and analogue. Assignee Suzhou Lanxite Biotechnology Co., Ltd., Peop. Rep. China. CN 107226790. (2017).