Mirabegron (formerly YM-178, trade name Myrbetriq) is a drug for the treatment of overactive bladder. It was developed by Astellas Pharma and was approved in the United States in July 2012. Mirabegron activates the β3 adrenergic receptor in the detrusor muscle in the bladder, which leads to muscle relaxation and an increase in bladder capacity.
Vedantham, Ravindra; Kandagatla, Bhaskar; Vyala, Sunitha; Raju, V. V. N. K. V. Prasada; Cherukupalli, Praveen; Iqbal, Javed; Dahanukar, Vilas H.; Kagga, Mukkanti; Bandichhor, Rakeshwar; Oruganti, Srinivas. Practical synthesis of Mirabegron. Journal of Chemical and Pharmaceutical Research. Volume 7. Issue 4. Pages 1473-1478. Journal; Online Computer File. (2015).
Xu, Guiqing; Mao, Shen; Mao, Longfei; Jiang, Yuqin; Zhou, Yong; Shen, Jiaxuan; Dong, Wenpei. Study on a New Method for Synthesis of Mirabegron. Journal of Heterocyclic Chemistry. Volume 54. Issue 5. Pages 2703-2707. Journal; Online Computer File. (2017).
De Angelis, Sonia; Carlucci, Claudia; de Candia, Modesto; Rebuzzini, Gabriele; Celestini, Paolo; Riscazzi, Massimiliano; Luisi, Renzo; Degennaro, Leonardo. Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process. Catalysis Today. Volume 308. Pages 81-85. Journal; Online Computer File. (2018).
Zhang, Lei; Tan, Zhimin; Jiao, Huirong; Qiu, Pengcheng; Zhang, Fuli. Synthesis of related substance of mirabegron. Zhongguo Yiyao Gongye Zazhi. Volume 45. Issue 1. Pages 9-12. Journal. (2014).
: Jung, In Hwa; Lee, In Gyu; Mo, Gil Ung; Han, Hae Su; Han, Ga Ram; Shin, Jae Won; Kim, Hyeon Jeong; Kim, A. Reum; Jung, Gi Won; Ahn, Ji Hun. Preparation of salts of amide derivatives. Assignee Sungwun Pharmacopia Co., Ltd., S. Korea. KR 2018138058. (2018).
Shankar, Rama; Chavhan, Bhausaheb; Tummalapalli, Umasankara Sastry; Talatala, Appi Reddy; Pareddi, Gandhi. An improved process for the preparation of Mirabegron. Assignee Mylan Laboratories Ltd., India. IN 2013CH02517. (2016).
Pradhan, Nitin Sharadchandra; Patil, Nilesh Sudhir; Walavalkar, Rajesh Ramchandra; Kulkarni, Nilesh Subhash; Rawool, Santosh Namdev; Awate, Purushottam Ekanath. A process for the preparation of mirabegron and its intermediates. Assignee Wanbury Ltd., India. IN 2014MU02534. (2016).
Li, Wei; Mao, Shen; Mao, Longfei; Jiang, Yuqin; Zhang, Yingui; Yuan, Lishuang; Xu, Guiqing; Dong, Wenpei; Jiang, Tao. Process for the preparation of mirabegron. Assignee Henan Normal University, Peop. Rep. China. CN 105111165. (2015).
Hu, Fan; Wang, Shenyong; Jia, Xinzan; Wang, Xiaojun; Hu, Junkai. Process for synthesis of Mirabegron. Assignee Suzhou Uugene Biopharma Co., Ltd., Peop. Rep. China. CN 103193730. (2013).
