Miltefosine is an orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma).
Xu, Fangming; Wang, Haibo; Zhao, Jie; Liu, Xiangsheng; Li, Dandan; Chen, Chaojian; Ji, Jian. Chiral Packing of Cholesteryl Group as an Effective Strategy To Get Low Molecular Weight Supramolecular Hydrogels in the Absence of Intermolecular Hydrogen Bond. Macromolecules (Washington, DC, United States). Volume 46. Issue 11. Pages 4235-4246. Journal; Online Computer File. (2013).
Zaffalon, Pierre-Leonard; Zumbuehl, Andreas. BODP - a versatile reagent for phospholipid synthesis. Synthesis. Issue 5. Pages 778-782. Journal. (2011).
Xu, Lianyan L.; Berg, Lawrence J.; Jamin Keith, D.; Townsend, Steven D. An effective reagent to functionalize alcohols with phosphocholine. Organic & Biomolecular Chemistry. Volume 18. Issue 4. Pages 767-770. Journal; Online Computer File. (2020).
