/image/Pitavastatin-00.jpg "Pitavastatin (Calcium) - Synthetic Route")
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187.
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Zhu, Jianrong; Jin, Zhiping; Hua, Changhua; Chen, Jianyang. Intermediate used for preparing dihydroxy acid hydroxymethyl glutaryl coenzyme A reductase inhibitor, its preparation, and application. Assignee Zhejiang Jingxin Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103288871. (2013).
Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Samala Malla; Krishna, Bandi Vamsi. Novel polymorphs of pitavastatin calcium. Assignee Hetero Research Foundation, India. IN 2010CH03399. (2012).
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