Darifenacin, also known as UK-88525, is a medication used to treat urinary incontinence. Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate.
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Liu, Changhuan; Yu, Xiong; Yuan, Zhedong. Synthesis of (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide (darifenacin hydrobromide). Zhongguo Yiyao Gongye Zazhi. Shanghai Institute of Pharmaceutical Industry. Shanghai, Peop. Rep. China 200437. Volume 38. Issue 12. Pages 825-827. 2007
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Katkam, Srinivas; Vaddadi, Pattabhiramayya; Sunkara, Vishnuvardhan; Muttavarapu, Muralimohan; Kulkarni, Lalitha Dattatray; Sagyam, Rajeshwar Reddy; Pitta, Jaya Prakash; Buchnikonda, Ravinder; Munagala, Sridhar. Process for preparation of darifenacin. Assignee Dr. Reddy's Laboratories Ltd., India; Dr. Reddy's Laboratories, Inc. WO 2008100651. 2008
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Lorente Bonde-Larsen, Antonio; Rodriguez Lopez, Maria; Fernandez Sainz, Yolanda; Gutierrez Fuentes, Luis Gerardo. Process for preparation of 1,3-difunctionalized pyrrolidines from 3-hydroxypyrrolidines. Assignee Ragactives, S.L., Spain. EP 2236509. 2010
