Ingenol mebutate, also known as ingenol-3-angelate, is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. Ingenol Mebutate was approved for the topical treatment of actinic keratosis. Ingenol mebutate has also been found to be useful for reactivating latent HIV virus in cells taken from individuals who have tested negative for signs of the disease following extended courses of anti-retroviral drugs, raising the possibility that this drug may be used to expose the last traces of virus, and thus potentially provide a permanent cure for HIV infection.
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Liang, Xifu. Process for the preparation of ingenol-3-angelate from 20-deoxy-ingenol. Assignee LEO Laboratories Limited, Ire. WO 2014012836. (2014).
Liang, Xifu; Hoegberg, Thomas; Grue-Soerensen, Gunnar; Moody, Thomas S.; Rowan, Andrew S. Enzymatic process of the preparation of ingenol-3-angelate. Assignee Leo Pharma A\/S, Den. WO 2013110753. (2013).
Hoegberg, Thomas; Grue-Soerensen, Gunnar; Liang, Xifu; Horneman, Anne Marie; Petersen, Anders Klarskov. A method of producing ingenol-3-angelate from ingenol. Assignee Leo Pharma A\/S, Den. WO 2012010172. (2012).
