Alectinib synthetic routes

CAT#: 314218 | Name: Elvitegravir | CAS#

Purchases for research

Description:

Elvitegravir, also known as GS-9137 ans EVG, is an integrase inhibitor used to treat HIV infection. The drug gained approval by the U.S. Food and Drug Administration on August 27, 2012 for use in adult patients starting HIV treatment for the first time as part of the fixed dose combination known as Stribild.

Synthetic Routes

Elvitegravir - Synthetic Route 1

Elvitegravir - Synthetic Route 1

Synthetic reference

Douša M, Stach J, Gibala P, Lemr K. Quantification of structurally related aliphatic amino alcohols in l-valinol by hydrophilic interaction liquid chromatography separation combined with postcolumn derivatization and fluorescence detection. J Sep Sci. 2016 Mar;39(5):851-6. doi: 10.1002/jssc.201501302. Epub 2016 Jan 28. PubMed PMID: 26697727.

Elvitegravir - Synthetic Route 2

Elvitegravir - Synthetic Route 2

Synthetic reference

Rádl, Stanislav & Stach, Jan & Píša, Ondřej & Cinibulk, Josef & Havlíček, Jaroslav & Zajícová, Markéta & Pekárek, Tomas. (2015). An Improved Synthesis of Elvitegravir. Journal of Heterocyclic Chemistry. n/a-n/a. 10.1002/jhet.2477.

Elvitegravir - Synthetic Route 3

Elvitegravir - Synthetic Route 3

Synthetic reference

Sato M, Kawakami H, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Matsuzaki Y, Yamataka K, Ikeda S, Shinkai H. Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem. 2009 Aug 13;52(15):4869-82. doi: 10.1021/jm900460z. PubMed PMID: 19719237.

Elvitegravir - Synthetic Route 4

Elvitegravir - Synthetic Route 4

Synthetic reference

Sato M, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Kawakami H, Matsuzaki Y, Watanabe W, Yamataka K, Ikeda S, Kodama E, Matsuoka M, Shinkai H. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem. 2006 Mar 9;49(5):1506-8. PubMed PMID: 16509568.

Elvitegravir - Synthetic Route 5

Elvitegravir - Synthetic Route 5

Synthetic reference

Satoh, Motohide; Motomura, Takahisa; Matsuda, Takashi; Kondo, Kentaro; Ando, Koji; Matsuda, Koji; Miyake, Shuji; Uehara, Hideto. Preparation of stable crystals of a 4-oxoquinoline anti-HIV compound. WO 2005113508. (Assignee Japan Tobacco Inc., Japan)

Elvitegravir - Synthetic Route 6

Elvitegravir - Synthetic Route 6

Synthetic reference

Matsuda, Koji; Ando, Koji; Ohki, Shigeji; Yamasaki, Takahiro; Hoshi, Jun-Ichi. Process for production of highly pure quinolone compound. WO 2007063869. (Assignee Japan Tobacco Inc., Japan)

Elvitegravir - Synthetic Route 7

Elvitegravir - Synthetic Route 7

Synthetic reference

Dowdy, Eric; Chen, Xi; Pfeiffer, Steven. Process and intermediates for preparing 4-oxo-quinolone compounds from dimethoxybenzoic acid via cyclization reaction useful as HIV integrase inhibitors. WO 2008033836. (Assignee Gilead Sciences, Inc., USA)

Elvitegravir - Synthetic Route 8

Elvitegravir - Synthetic Route 8

Synthetic reference

Vellanki, Siva Rama Prasad; Dhake, Vilas Nathu; Ravi, Satyanarayana; Nuchu, Ravi; Puliyala, Ravindra; Shaik, Mahaboob Basha; Datta, Debashish. An improved process for the preparation of elvitegravir. WO 2011004389. (Assignee Matrix Laboratories Ltd., India)

Elvitegravir - Synthetic Route 9

Elvitegravir - Synthetic Route 9

Synthetic reference

Li, Jinliang; Zhao, Nan; Liu, Yu. Elvitegravir intermediates and preparation method and application thereof. CN 103819402. (Assignee Shanghai Desano Chemical Pharmaceutical Co., Ltd., Peop. Rep. China)

Elvitegravir - Synthetic Route 10

Elvitegravir - Synthetic Route 10

Synthetic reference

Rajan, Srinivasan Thirumalai; Eswaraiah, Sajja; Reddy, Ghojala Venkat; Reddy, Mallepally Venkat. Process for the preparation of elvitegravir and pharmaceutically acceptable salts and crystalline forms thereof. WO 2016193997 (Assignee MSN Laboratories Private Limited, India)

Elvitegravir - Synthetic Route 11

Elvitegravir - Synthetic Route 11

Synthetic reference

Ma, Shuai; Zhao, Jun; Du, Weihong; Cao, Shenghua. Synthesis of elvitegravir. Zhongguo Yiyao Gongye Zazhi. Sichuan Industrial Institute of Antibiotics. China National Pharmaceutical Group Co. Chengdu, Sichuan Province, Peop. Rep. China 610052. Volume 45. Issue 1. Pages 5-8. 2014.