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Alectinib synthetic routes

Cilostazol - Synthetic Route

CAT#: 317527 | Name: Cilostazol | CAS# 73963-72-1

Purchases for research

Description:

Cilostazol is a quinolinone-derivative medication used in the alleviation of the symptom of claudication in individuals with peripheral vascular disease. Cilostazol is a phosphodiesterase inhibitor with therapeutic focus on cyclic adenosine monophosphate (cAMP). It inhibits platelet aggregation and is a direct arterial vasodilator. Its main effects are dilation of the arteries supplying blood to the legs and decreasing platelet coagulation. It is under the trade name Pletal.

Synthetic Routes

Cilostazol - Synthetic Route 1

Cilostazol - Synthetic Route 1

Synthetic reference

Chandgude, Ajay L.; Doemling, Alexander. Convergent Three-Component Tetrazole Synthesis. European Journal of Organic Chemistry. Department of Drug Design. University of Groningen. Groningen, Neth. 9713 AV. Volume 2016. Issue 14.Pages 2383-2387. 2016

Cilostazol - Synthetic Route 2

Cilostazol - Synthetic Route 2

Synthetic reference

Nishi, Takao; Tabusa, Fujio; Tanaka, Tatsuyoshi; Shimizu, Takefumi; Kanbe, Toshimi; Kimura, Yukio; Nakagawa, Kazuyuki. Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and related compounds. Chemical & Pharmaceutical Bulletin. Tokushima Res. Inst. Otsuka Pharm. Co., Ltd. Tokushima, Japan 771-01. Volume 31. Issue 4. Pages 1151-7. 1983

Cilostazol - Synthetic Route 3

Cilostazol - Synthetic Route 3

Synthetic reference

Aki, Shinji; Nishi, Takao; Minamikawa, Jun-ichi. An efficient lutidine-assisted etherification of phenols with alkyl chloride in water. Chemistry Letters. Process Research Laboratory, 2nd Tokushima Factory. Otsuka Pharmaceutical Co., Ltd. Tokushima, Japan 771-0182. Volume 33. Issue 7. Pages 940-941. 2004

Cilostazol - Synthetic Route 4

Cilostazol - Synthetic Route 4

Synthetic reference

Zhao, Hailong; Sheng, Jinhuo; Zhang, Xiaowei; Zhao, Binfeng; Qian, Zhiying; Chen, Xiaohong. Process for preparation of cilostazol. Assignee Zhejiang Kinglyuan Pharmaceutical Co., Ltd., Peop. Rep. China. CN 105111190. 2015

Cilostazol - Synthetic Route 5

Cilostazol - Synthetic Route 5

Synthetic reference

Kankan, R. N.; Rao, D. R.; Narayan, B. M. Preparation of cilostazol. Assignee Cipla Limited, India. IN 2003MU00444. 2005

Cilostazol - Synthetic Route 6

Cilostazol - Synthetic Route 6

Synthetic reference

Zhang, Yun. Method for manufacturing Cilostazol. CN 104744436. 2015

Cilostazol - Synthetic Route 7

Cilostazol - Synthetic Route 7

Synthetic reference

Mendelovichi, Marioara; Finkelstein, Nina; Pilarksi, Gideon. Preparation of cilostazol. Assignee Teva Pharmaceutical Industries Ltd., Israel; Teva Pharmaceuticals USA, Inc. WO 2002014283. 2002