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Alectinib synthetic routes

Lisdexamfetamine (dimesylate) - Synthetic Route

CAT#: 315245 | Name: Lisdexamfetamine (dimesylate) | CAS# 608137-32-2 / 608137-33-3

Purchases for research

Description:

Lisdexamphetamine (L-lysine-D-amphetamine; sold as Vyvanse) is a psychostimulant prodrug of the phenethylamine and amphetamine chemical classes. Its molecular structure consists of dextroamphetamine coupled with the essential amino acid L-lysine. Lisdexamfetamine dimesylate is discontinued (DEA controlled substance).

Synthetic Routes

Lisdexamfetamine (dimesylate) - Synthetic Route 1

Lisdexamfetamine (dimesylate) - Synthetic Route 1

Synthetic reference

Jass, Paul Alan; Johnson, Todd Jeffrey; Douglas, Jason Scott; Schiesher, Matthew Wendell. Methods and compositions for preparation of amphetamine conjugates and salts thereof. Assignee Cambrex Charles City, Inc., USA. WO 2010148305. (2010).

Lisdexamfetamine (dimesylate) - Synthetic Route 2

Lisdexamfetamine (dimesylate) - Synthetic Route 2

Synthetic reference

Popp, Karl; Meckler, Harold. Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms. Assignee Chemapotheca, LLC, USA. US 20180243241. (2018).

Lisdexamfetamine (dimesylate) - Synthetic Route 3

Lisdexamfetamine (dimesylate) - Synthetic Route 3

Synthetic reference

Goudriaan, Pietertie Elisabeth; Kaiser, Jasper; Ibrahim, Hemen; Verspui, Govert Arie; Cox, Douglas Phillip. Process for the preparation of lisdexamfetamine and related derivatives. Assignee Noramco, Inc., USA. WO 2017003721. (2017).

Lisdexamfetamine (dimesylate) - Synthetic Route 4

Lisdexamfetamine (dimesylate) - Synthetic Route 4

Synthetic reference

Bauer, Michael J.; Callen, Gary Richard; Humphrey, Judi Christine; Johnson, Todd Jeffrey; Schiesher, Matthew Wendell. Methods for preparing lisdexamfetamine and its salts. Assignee Cambrex Charles City, Inc., USA. US 20120157706. (2012).

Lisdexamfetamine (dimesylate) - Synthetic Route 5

Lisdexamfetamine (dimesylate) - Synthetic Route 5

Synthetic reference

Rajamannar, Thennati; Srinivasu, Kilaru; Pawar, Sujit Sridhar; Patel, Nileshkumar Sureshbhai. Process for preparation of lisdexamphetamine. Assignee Sun Pharmaceutical Industries Limited, India. WO 2017098533. (2017).