Alectinib synthetic routes

CAT#: 314223 | Name: Gadobutrol | CAS# 138071-82-6

Purchases for research

Description:

Gadobutrol is a gadolinium-based MRI contrast agent (GBCA). It received marketing approval in Canada and in the United States. As of 2007, it was the only GBCA approved at 1.0 molar concentrations. Gadobutrol is marketed by Bayer Schering Pharma as Gadovist, and by Bayer HealthCare Pharmaceuticals as Gadavist.

Synthetic Routes

Gadobutrol - Synthetic Route 1

Gadobutrol - Synthetic Route 1

Synthetic reference

Wang, Chungui; Guo, Shuai; Zhang, Xuyang; Huo, Xianghong; Wang, Qi; Wang, Lichun; Wang, Jingyi. Method for preparing gadobutrol. Assignee Tianjin Kelun Pharmaceutical Research Co., Ltd., Peop. Rep. China; Sichuan Kelun Pharmaceutical Research Co., Ltd. CN 109293592. (2019).

Gadobutrol - Synthetic Route 2

Gadobutrol - Synthetic Route 2

Synthetic reference

Long, Xiangtian; Tan, Junrong; Lu, Biao; Lai, Yingjie; Liang, Long; Xie, Dexun. Method for preparing high purity Gadobutrol. Assignee Chem-Stone Co., Ltd., Peop. Rep. China. CN 108299322. (2018).

Gadobutrol - Synthetic Route 3

Gadobutrol - Synthetic Route 3

Synthetic reference

Long, Xiangtian; Zhou, Lei; Lai, Yingjie; Bai, Libin; Cao, Benwen; Tan, Junrong; Liang, Long; Xie, Dexun. Method for preparing high-yield gadobutrol using tetraazacyclododecane monoformaldehyde. Assignee Chem-Stone Co., Ltd., Peop. Rep. China. CN 108047151. (2018).

Gadobutrol - Synthetic Route 4

Gadobutrol - Synthetic Route 4

Synthetic reference

Yuan, Jinqiao; Zhu, Laifa; Liu, Hu. Preparation method of high-purity gadobutrol. Assignee Jiashi (Hunan) Pharmaceutical Technology Co., Ltd., Peop. Rep. China. CN 106543094. (2017).

Gadobutrol - Synthetic Route 5

Gadobutrol - Synthetic Route 5

Synthetic reference

Zhu, Quan; Shi, Xinghua; Zheng, Zhaoguang; Ou, Xiaomin; Tang, Dan; Wang, Rushang; Gu, Fei; He, Bao; Duan, Tingting; Cheng, Huiquan; Huang, Xiaoling; Huang, Yunbin; Huang, Yanxia; Chen, Yuling. Method for preparing contrast agents for magnetic resonance imaging. Assignee Guangzhou Consun Pharmaceutical Research Co., Ltd., Peop. Rep. China. CN 102399199. (2012).

Gadobutrol - Synthetic Route 6

Gadobutrol - Synthetic Route 6

Synthetic reference

Argese, Maria; Ripa, Giorgio. Preparation of 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one for the preparation of tetraazamacrocycles. Assignee Bracco S.P.A., Italy; Dibra S.P.A. WO 9905145. (1999).