Alectinib synthetic routes

CAT#: 599049 | Name: Edoxaban | CAS#

Purchases for research

Description:

Edoxaban (INN, codenamed DU-176b, trade name Lixiana) is a potent, selective factor Xa inhibitor, which has good oral bioavailability. Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is being developed by Daiichi Sankyo. It was approved in July 2011 in Japan for prevention of venous thromboembolisms (VTE) following lower-limb orthopedic surgery. It was also approved by the FDA in January 2015 for the prevention of stroke and non–central-nervous-system systemic embolism.

Synthetic Routes

Edoxaban - Synthetic Route 1

Edoxaban - Synthetic Route 1

Synthetic reference

Anon.Crystalline form of N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide. Volume 16. Issue 12A. Pages 1-2. (IP.com Journal)

Edoxaban - Synthetic Route 2

Edoxaban - Synthetic Route 2

Synthetic reference

Noguchi, Shigeru; Koyama, Takeo. Process for the preparation of oxadiazole compounds containing cyclohexanediamine moiety. WO 2008156159. (Assignee Daiichi Sankyo Company, Limited, Japan)

Edoxaban - Synthetic Route 3

Edoxaban - Synthetic Route 3

Synthetic reference

Kawanami, Koutarou. Method for the preparation of optically active diamine derivative. WO 2010104106. (Assignee Daiichi Sankyo Company,Limited, Japan)

Edoxaban - Synthetic Route 4

Edoxaban - Synthetic Route 4

Synthetic reference

Bodhuri, Prabhudas; Karadeolian, Avedis; Cammisa, Eduardo Gustavo; Green, Stuart P.; Green, Melanie R. A.; Ceccarelli, Alfredo Paul. Processes for the preparation of edoxaban intermediates and salts thereof. US 20180179226. (Assignee Apotex Inc., Can.)

Edoxaban - Synthetic Route 5

Edoxaban - Synthetic Route 5

Synthetic reference

Koyama, Takeo; Kondo, satoshi. Process for the preparation of diamine derivative. WO 2010104078. (Assignee Daiichi Sankyo Company,Limited, Japan)

Edoxaban - Synthetic Route 6

Edoxaban - Synthetic Route 6

Synthetic reference

Nakamura, Yoshitaka; Mukesh, Kumar Madhra; Inamdar, Murad Ismail. A process for the preparation of bromooxabicyclooctanone. WO 2014081047. (Assignee Daiichi Sankyo Company, Limited, Japan)

Edoxaban - Synthetic Route 7

Edoxaban - Synthetic Route 7

Synthetic reference

Nakamura, Yoshitaka; Michida, Makoto; Kaneda, Takeshi. Method for preparing optically active diamine derivatives. WO 2014157653. (Assignee Daiichi Sankyo Company Limited, Japan)

Edoxaban - Synthetic Route 8

Edoxaban - Synthetic Route 8

Synthetic reference

Takayanagi, Yoshihiro; Furuya, Yukito; Nakamura, Yoshitaka. Method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one. WO 2014157612. (Assignee Daiichi Sankyo Company, Limited, Japan)

Edoxaban - Synthetic Route 9

Edoxaban - Synthetic Route 9

Synthetic reference

Ueda, Tsuyoshi. Preparation of activated blood coagulation factor X (FXa) inhibitor compounds under mild conditions. WO 2015125710. (Assignee Daiichi Sankyo Company,Limited, Japan)

Edoxaban - Synthetic Route 10

Edoxaban - Synthetic Route 10

Synthetic reference

Li, Ying; Wang, Qingpeng; Liu, Zhikang. Process for preparation of edoxaban free base. CN 105753888. (Assignee Lepu Pharmaceutical Co., Ltd., Peop. Rep. China)