Bivalirudin, also known as BG-8967, is a specific and reversible direct thrombin inhibitor (DTI). Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis). Bivalirudin overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin.
Okada, Yohei; Suzuki, Hideaki; Nakae, Takashi; Fujita, Shuji; Abe, Hitoshi; Nagano, Kazuo; Yamada, Toshihide; Ebata, Nobuyoshi; Kim, Shokaku; Chiba, Kazuhiro. Tag-assisted liquid-phase peptide synthesis using hydrophobic benzyl alcohols as supports. Journal of Organic Chemistry. Department of Applied Biological Science. Tokyo University of Agriculture and Technology. 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan 183-8509. Volume 78. Issue 2. Pages 320-327. 2013
Takahashi, Daisuke; Inomata, Tatsuji; Fukui, Tatsuya. AJIPHASE: A highly efficient synthetic method for one-pot peptide elongation in the solution phase by an Fmoc strategy. Angewandte Chemie, International Edition. Research Institute for Bioscience Products and Fine Chemicals. AJINOMOTO Co., Inc. Kawasaki, Japan 210-8681. Volume 56. Issue 27. Pages 7803-7807. 2017
