Eliglustat, also known as GENZ-112638, (trade name Cerdelga) is a treatment for Gaucher's disease developed by Genzyme Corp that was approved by the FDA August 2014. Commonly used as the tartrate salt, Eliglustat is believed to work by inhibition of glucosylceramide synthase.
Sun, Guodong; Jian, Weilin; Luo, Zhonghua; Sun, Tengfei; Li, Chao; Zhang, Jiancun; Wang, Zhongqing. Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation. Organic Process Research & Development. Volume 23. Issue 6. Pages 1204-1212. Journal; Online Computer File. (2019).
Liu, Xiaoyu; Li, Xiaoyu; Yang, Hongguang; Shi, Xiang; Yang, Feilong; Jiao, Xiaozhen; Xie, Ping. Concise and efficient synthesis of eliglustat. Synthetic Communications. Volume 48. Issue 5. Pages 594-600. Journal; Online Computer File. (2018).
van den Berg, Richard J. B. H. N.; van Rijssel, Erwin R.; Ferraz, Maria Joao; Houben, Judith; Strijland, Anneke; Donker-Koopman, Wilma E.; Wennekes, Tom; Bonger, Kimberly M.; Ghisaidoobe, Amar B. T.; Hoogendoorn, Sascha; van der Marel, Gijsbert A.; Codee, Jeroen D. C.; Overkleeft, Herman S.; Aerts, Johannes M. F. G. Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors. ChemMedChem. Volume 10. Issue 12. Pages 2042-2062. Journal; Online Computer File. (2015).
Srinivasan, Thirumalai Rajan; Sajja, Eswaraiah; Ghojala, Venkat Reddy; Sagyam, Rajeshwar Reddy; Mallepally, Venkat Reddy; Koppera, Ravinder Reddy; Singavarapu, Adilakshmi; Rangineni, Srinivasulu. Stable N-[(1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]octanamide (2R,3R)-2,3-dihydroxysuccinate premix and process for preparation thereof. Assignee MSN Laboratories Private Limited, R&D Center, India. WO 2019082209. (2019).
Liu, Yu; Yu, Guangneng; Zheng, Zhiguo. Synthetic method of eliglustat and its intermediate. Assignee Zhejiang Ausun Pharmaceutical Co., Ltd., Peop. Rep. China. WO 2018171173. (2018).
Liu, Suyun; Feng, Piaochun. Eliglustat hemitartrate crystal form, preparation method and pharmaceutical composition. Assignee Beijing Qihui Medical Devices Co., Ltd., Peop. Rep. China. CN 107445938. (2017).
Gu, Haidong; Yuan, Weifeng; Sun, Yuejun; Luo, Huan. Process for the preparation of Eliglustat tartrate. Assignee Beijing Sunshine Nuohe Medicine Research Co., Ltd., Peop. Rep. China; Jiangsu Yongan Pharmaceutical Co., Ltd. CN 106349210. (2017).
