Segesterone acetate, also known as ST-1435 or nestorone, is a progesterone receptor agonist, which is a potential female-contraceptive agent. Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.
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