Alectinib synthetic routes

CAT#: 315341 | Name: Deflazacort | CAS#

Purchases for research

Description:

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It is sold in the United Kingdom by Shire under the trade name Calcort. in Brazil as Cortax, Decortil, and Deflanil, and in Honduras as Flezacor. It is not available in the United States. Deflazacort is a prodrug. Its potency is around 70–90% that of prednisone.

Synthetic Routes

Deflazacort - Synthetic Route 1

Deflazacort - Synthetic Route 1

Synthetic reference

Nathansohn G, Winters G, Aresi V. Steroids possessing nitrogen atoms. IV. Further studies on the synthesis of [17alpha,16alpha-d]-oxazolino-corticoids. Steroids. 1969 Mar;13(3):383-97. PubMed PMID: 5789709.

Deflazacort - Synthetic Route 2

Deflazacort - Synthetic Route 2

Synthetic reference

Xu, Runxing. Process for preparing deflazacort. CN 108484714. (Assignee Yueyang Huanyu Pharmaceutical Co., Ltd., Peop. Rep. China)

Deflazacort - Synthetic Route 3

Deflazacort - Synthetic Route 3

Synthetic reference

Liu, Xiang; He, Lian; Zhang, Jing. Method for synthesizing Deflazacort. CN 105777852. (Assignee Kamp Pharmaceuticals Co., Ltd., Peop. Rep. China)

Deflazacort - Synthetic Route 4

Deflazacort - Synthetic Route 4

Synthetic reference

Forte, Luigi; Cancellieri, Calogero. Process for preparation of (11β,16β)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione (deflazacort). WO 9721722. (Assignee Gruppo Lepetit S.P.A., Italy)

Deflazacort - Synthetic Route 5

Deflazacort - Synthetic Route 5

Synthetic reference

Liu, Xirong; Xie, Laibin; Hu, Aiguo. Improved method for synthesis of Deflazacort from 11β-hydroxypregna-1,4-diene-3,20-dione[17α,16α-d]-2'-methyloxazoline. CN 101418032. (Assignee Hunan Steroid Chemicals Co., Ltd., Peop. Rep. China)

Deflazacort - Synthetic Route 6

Deflazacort - Synthetic Route 6

Synthetic reference

Zhang, Shubing; Xie, Yanmin. Method for preparation of antiinflammatory and antiallergy agent Deflazacort. CN 102942613. (Assignee Tianjin Derchemist Science & Technology Co., Ltd., Peop. Rep. China)

Deflazacort - Synthetic Route 7

Deflazacort - Synthetic Route 7

Synthetic reference

Li, Yaling; Wang, Shuli. Method for reducing 11-site ketone group of steroid. CN 105622713. (Assignee Tianjin Kingyork Group Co., Ltd., Peop. Rep. China)

Deflazacort - Synthetic Route 8

Deflazacort - Synthetic Route 8

Synthetic reference

Hu, Aiguo; Xie, Laibin; Wu, Laixi. Preparation method of Deflazacort from 16(17)α-epoxyprednisolone by amination ring-opening, condensation ring-closing and ethyl esterification. CN 106008660. (Assignee Hunan Kerey Pharmaceutical Co., Ltd., Peop. Rep. China)

Deflazacort - Synthetic Route 9

Deflazacort - Synthetic Route 9

Synthetic reference

Deng, Lianqiang; Li, Mingqing. Preparation method of Deflazacort from 11-hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione as starting material. CN 106397532. (Assignee Jiangxi Yuneng Pharmaceutical Co., Ltd., Peop. Rep. China)