Aclidinium bromide is a long-acting anticholinergic bronchodilator approved by the FDA in 2012 for use in the management of chronic obstructive pulmonary disease (COPD) which includes chronic bronchitis and emphysema. It is not however used for acute exacerbations. Aclidinium bromide is an inhalation powder promoted by Forest Pharmaceuticals in the US under the trade name Tudorza Pressair. It is also manufactured and marketed by Menarini Pharmaceuticals in the EU under the trade name Bretaris Genuair, in the UK as Eklira Genuair and in the Canada as Tudorza Genuair.
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Reddy, G. Nithun; Reddy, G. Samhitha; Reddy, G. Madaalasa; Ramani, M.; Reddy, G. Pratap. A process for preparing aclidinium bromide and intermediates thereof. Assignee GBR Laboratories Pvt. Ltd., India; Rachana Pharma Tech. IN 201741005254. (2018).
Huang, Heyi; Zhang, Xin; Tao, Yan; Zhou, Yingli; Jiang, Wenmin; Liu, Ying. high-purity and high-yield preparation method of Aclidinium bromide suitable for industrialized production. Assignee Guangzhou Maidakang Pharmaceutical Co., Ltd., Peop. Rep. China. CN 106831756. (2017).
Zhao, Shengyin; An, Yulong; Wang, Ming. Preparation method of choline M receptor antagonist Aclidinium bromide. Assignee Donghua University, Peop. Rep. China; Shanghai Fangyu Health Pharmaceutical Technology Co., Ltd. CN 105440030. (2016).
