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Alectinib synthetic routes

Abiraterone Acetate - Synthetic Route

CAT#: 200030 | Name: Abiraterone Acetate | CAS# 154229-18-2

Purchases for research

Description:

Abiraterone acetate is an FDA approved drug, and is an orally active acetate ester of the steroidal compound abiraterone with antiandrogen activity. Abiraterone acetate was approved by the U.S. Food and Drug Administration (FDA) in April 2011. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. FDA Approval this drug in May 2011.

Synthetic Routes

Abiraterone Acetate - Synthetic Route 1

Abiraterone Acetate - Synthetic Route 1

Synthetic reference

Madhra, Mukesh Kumar; Sriram, Hari Mohan; Inamdar, Murad; Sharma, Mukesh Kumar; Prasad, Mohan; Joseph, Sony. Improved Procedure for Preparation of Abiraterone Acetate. Organic Process Research & Development. Volume 18. Issue 4. Pages 555-558. Journal; Online Computer File. (2014).

Abiraterone Acetate - Synthetic Route 2

Abiraterone Acetate - Synthetic Route 2

Synthetic reference

Madhra, Mukesh Kumar; Sriram, Hari Mohan; Inamdar, Murad; Sharma, Mukesh Kumar; Prasad, Mohan; Joseph, Sony. Improved Procedure for Preparation of Abiraterone Acetate. Organic Process Research & Development. Volume 18. Issue 4. Pages 555-558. Journal; Online Computer File. (2014).

Abiraterone Acetate - Synthetic Route 3

Abiraterone Acetate - Synthetic Route 3

Synthetic reference

Li, Zhenfei; Alyamani, Mohammad; Li, Jianneng; Rogacki, Kevin; Abazeed, Mohamed; Upadhyay, Sunil K.; Balk, Steven P.; Taplin, Mary-Ellen; Auchus, Richard J.; Sharifi, Nima. Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy. Nature (London, United Kingdom). Volume 533. Issue 7604. Pages 547-551. Journal; Online Computer File. (2016).

Abiraterone Acetate - Synthetic Route 4

Abiraterone Acetate - Synthetic Route 4

Synthetic reference

Li, Yaling; Wang, Shuli. Method for synthesizing Abiraterone acetate. Assignee Tianjin Kingyork Group Co., Ltd., Peop. Rep. China. CN 104558091. (2015).

Abiraterone Acetate - Synthetic Route 5

Abiraterone Acetate - Synthetic Route 5

Synthetic reference

Xie, Zhixiang; Guo, Yueming. Method for preparing Abiraterone acetate. Assignee Lanzhou University, Peop. Rep. China. CN 105622703. (2016).

Abiraterone Acetate - Synthetic Route 6

Abiraterone Acetate - Synthetic Route 6

Synthetic reference

Kuo, Lung-Huang; Fang, Hsiao-Ping; Wu, Ming-Feng; Chang, Yu-Sheng. Process for the preparation of abiraterone and intermediates thereof. Assignee ScinoPharm Taiwan, Ltd., Taiwan; ScinoPharm Singapore Pte, Ltd. WO 2014207567. (2014).

Abiraterone Acetate - Synthetic Route 7

Abiraterone Acetate - Synthetic Route 7

Synthetic reference

Marom, Ehud; Rubnov, Shai; Mizhiritskii, Michael. Process and intermediates for the preparation of abiraterone acetate. Assignee Mapi Pharma Ltd., Israel. WO 2014016830. (2014).