Gadoxetate Disodium is a liver-specific magnetic resonance imaging (MRI) contrast agent. Gadoxetate Disodium is preferentially taken up by normal functioning hepatocytes, so normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced.
Novel process for the preparation of gadolinium complex of (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecanedioic acid disodium (gadoxetate disodium); Pullagurla, Manik Reddy; Pitta, Bhaskar Reddy; Namani, Suresh Babu; Rangisetty, Jagadeesh Babu; Assignee Biophore India Pharmaceuticals Pvt. Ltd., India; 2017; Patent Information; Dec 07, 2017; WO 2017208258 A1
Process for preparation of gadoxetate disodium and intermediates thereof; Leng, Chuanxin; Wang, Yubing; Zhang, Minghui; Fan, Chuanwen; Lin, Dong; Liu, Peiyuan; Zhang, Yonghui; Assignee Qilu Pharmaceutical Co., Ltd., Peop. Rep. China; 2013; Patent Information; Dec 04, 2013; CN 103420862 A
