Trifarotene is a gamma retinoic acid receptor agonist. Trifarotene is in development as a topical cream for the treatment of skin disorders, including acne vulgaris, cutaneous t-cell lymphoma and lamellar ichthyosis.
Biadatti, Thibaud; Dumais, Laurence; Soulet, Catherine; Talano, Sandrine; Daver, Sebastien. Preparation of [1,1':3',1'']terphenyl-4-carboxylic acid and esters a novel ligands modulating retinoic acid receptors (RAR), and use thereof in human medicine and in cosmetics. Assignee Galderma Research & Development, S.N.C., Fr. WO 2006066978. (2016).
