Ceftazidime is a broad-spectrum β-lactam antibiotic used as an antimicrobial agent. It is used for treating febrile neutropenia in patients with cancer. It is a third-generation cephalosporin. As a class, cephalosporins have activity against Gram-positive and Gram-negative bacteria. The balance of activity tips toward Gram-positive organisms for earlier generations; later generations of cephalosporins have more Gram-negative coverage. Ceftazidime is one of the few in this class with activity against Pseudomonas.
Masoud MS, Ali AE, Elasala GS, Kolkaila SA. Synthesis, spectroscopic, biological activity and thermal characterization of ceftazidime with transition metals. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 15;193:458-466. doi: 10.1016/j.saa.2017.12.060. Epub 2017 Dec 24. PubMed PMID: 29289744.
J. R. Anacona & Candy Patiño (2009) Metalloantibiotics: synthesis and antibacterial activity of ceftazidime metal complexes, Journal of Coordination Chemistry, 62:4, 613-621, DOI: 10.1080/00958970802291480
Aly, Aref & Osman, AH & Abo El-Maali, Nagwa & Al-Hazmi, Gamil. (2004). Thermal and photochemical behaviour of Zn(II) complexes of some cephalosporins. Journal of Thermal Analysis and Calorimetry. 75. 159-168. 10.1023/B:JTAN.0000017338.52247.76.
Datta, Debashish; Rai, Bishwa Prakash; Mehre, Kishor Gulabrao. A process for the manufacture of ceftazidime. IN 182120. (Assignee Lupin Laboratories Limited, India)
No Data
Zhou, Zijin; Luo, Xinzu; Chen, Feng; Liu, Huajian; Liu, Yuliang; Wang, Lei. Method for synthesis of Ceftazidime. CN 107266473. (Assignee Suzhou Zhonglian Chemical Pharmaceutical Co., Ltd., Peop. Rep. China)
Fu, Miaoqing; Zhao, Yeqing; Sun, Bin; Xu, Lei; Zhu, Xuwei; Ma, Qingshuang; Zhou, Baishui; Wang, Lei. Original-quality Ceftazime and pharmaceutical preparation. 105646541. (Assignee Zhongshan Jincheng Dobfar Pharmaceutical Co., Ltd., Peop. Rep. China; Shandong Jincheng Pharmaceuticals and Chemicals Co., Ltd.)
Zhou, Xuan; Shen, Qianwan; Liu, Ping. Method for preparing Ceftazidime for injections and avoiding product no-load. CN 104860964. (Assignee Sichuan Pharmaceutical, Inc., Peop. Rep. China)
Korda, Anna; Winiarski, Jerzy; Gwardiak, Katarzyna. Preparation of substituted at 3'-position quaternary ammonium derivatives of cephalosporin. PL 172379. (Assignee PAN, Instytut Chemii Organicznej, Pol.)
Mikolajczyk, Jerzy; Zukowski, Edward; Rusek, Dorota; Kurzynoga, Dariusz; Krejer, Anna. Method for the preparation of ceftazidime pentahydrate. PL 178361. (Assignee Bioton Sp.z o.o., Pol.)
Zheng, Yulin. Improved synthesis of ceftazidime. Zhongguo Yaowu Huaxue Zazhi. Volume 20. Issue 3. Pages 198-200.2010. Industrialization Research Center. Shanghai Asia Pioneer Pharmaceutical Co., Ltd. Shanghai, Peop. Rep. China 201203.
