Febuxostat, also known as Uloric and TMX-67, is a xanthine oxidase inhibitor used to treat hyperuricemia and chronic gout.
Process for the preparation of febuxostat and salts thereof; Birari, Dilip Ramdas; Rao, Dharmaraj Ramachandra; Kankan, Rajendra Narayanrao; Assignee Cipla Limited, India; Curtis, Philip Anthony 2011; Patent Information; Jun 23, 2011; WO 2011073617 A1
Process for the preparation of ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate and febuxostat; Huang, Qingyun; Huang, Huan; Assignee Anhui Qingyun Pharmaceutical & Chemical Co., Ltd., Peop. Rep. China 2014; Patent Information; Jun 25, 2014; CN 103880775 A
Synthesis and characterization of 2-(3-cyano-4-isobutyl oxyphenyl)-4-methyl-5-thiazole carboxylic acid; Liu, Chuan-fei; Wei, Jun-chao; Dai, Yan-feng Nanchang Daxue Xuebao, Likeban; Volume 35; Issue 3; Pages 238-240; Journal; 2011
Tsuchiya, Daisuke; Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo. Direct Oxidative Conversion of Methylarenes into Aromatic Nitriles. Organic Letters. Volume 15. Issue 16. Pages 4194-4197. 2013.
Reddy, Manne Satyanarayana; Rao, Gogulapati Venkata Panakala; Prasad, Gadamsetty. Process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat). Assignee MSN Laboratories Limited, India. WO 2011141933. (2011).
Li, Xiao Long; Qiu, Rui; Wan, Wei Li; Cheng, Xu; Hai, Li; Wu, Yong. Synthesis of the Major Metabolites of Febuxostat. Letters in Organic Chemistry. Volume 12. Issue 3. Pages 217-221. 2015.
Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Matta Ramakrishna; Krishna, Bandi Vamsi. Process for the preparation of febuxostat. Assignee Hetero Research Foundation, India. WO 2012168948. (2012).
Wang, Shaojie; Shi, Xiang. Method for synthesis of 2-(3-cyano-4-isobutoxy)phenyl-4-methyl-5-thiazolecarboxylate from 4-hydroxybenzonitrile. Assignee Shenyang Pharmaceutical University, Peop. Rep. China. CN 101863854. (2010).
Huang, Huan; Huang, Qingyun; Li, Kai; Zhang, Hongyuan. Preparation method of Febuxostat. Assignee Anhui Qingyun Pharmaceutical Co., Ltd., Peop. Rep. China. CN 109574951. (2019).
Zhou, Liyong; Huang, Weiping; Zeng, Weilin; Xu, Hongcai; Kang, Lu; Feng, Yujie; Lin, Yan. Method for preparing intermediate of febuxostat and application of said intermediate to prepare febuxostat. Assignee Jiangxi Synergy Pharmaceutical Co., Ltd., Peop. Rep. China. CN 108358866. (2018).
